Alterations in regulatory and locomotor behaviors following trimethyltin exposure in the rat: a time and dose analysis.


Journal Article

Adult male hooded rats were tested pretreatment for spontaneous alternation and open-field behaviors. Animals were then intubated with either 5 or 7 mg/kg trimethyltin chloride (TMT Cl) or the isotonic saline vehicle. Post-treatment, animals were again tested for spontaneous alternation and open-field behaviors during three separate 5-day periods: days 14-18, days 56-60 and days 106-110. Additionally, both body weight and water intake were assessed. The larger dose of TMT Cl resulted in significant, but temporary reduction in body weight, elevated water intake for approximately 3 weeks, and a persistent increase in open-field activity. The smaller dose of TMT Cl resulted in elevated water intake for approximately 3 weeks and a temporary increase in open-field activity. Since the tendency to enter choice arms decreased in all groups across testing sessions, the effects of TMT Cl on spontaneous alternation could not be accurately assessed.

Full Text

Duke Authors

Cited Authors

  • Johnson, CT; Dunn, A; Robinson, C; Walsh, TJ; Swartzwelder, HS

Published Date

  • June 1, 1984

Published In

Volume / Issue

  • 47 / 2

Start / End Page

  • 99 - 106

PubMed ID

  • 6462539

Pubmed Central ID

  • 6462539

Electronic International Standard Serial Number (EISSN)

  • 1872-7972

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(84)90413-0


  • eng