Endothelial Cell Vascular Smooth Muscle Cell Co-Culture Assay For High Throughput Screening Assays For Discovery of Anti-Angiogenesis Agents and Other Therapeutic Molecules.

Published

Journal Article

Drug development for many diseases would be aided greatly by accurate in vitro model systems that replicate key elements of in vivo physiology. The recent development of co-culture systems of endothelial cells and vascular smooth muscle cells can be extended to high throughput systems for the identification of compounds for angiogenesis, vascular repair and hypertension. In this review, the various co-culture systems are reviewed and biological interactions between endothelial cells and vascular smooth muscle cells are discussed. Key considerations in the design of high throughput systems are presented and selected examples are discussed.

Full Text

Duke Authors

Cited Authors

  • Truskey, GA

Published Date

  • October 2010

Published In

Volume / Issue

  • 2010 / 1

Start / End Page

  • 171 - 181

PubMed ID

  • 21278926

Pubmed Central ID

  • 21278926

Electronic International Standard Serial Number (EISSN)

  • 1179-1381

International Standard Serial Number (ISSN)

  • 1179-1381

Digital Object Identifier (DOI)

  • 10.2147/IJHTS.S13459

Language

  • eng