Reorganization of the host cytoskeleton by the intracellular pathogen Chlamydia trachomatis.


Journal Article

Chlamydiae are obligate intracellular pathogens that cause a wide range of human diseases. Chlamydia resides in a membrane bound vacuole ("inclusion") that expands to accommodate replicating bacteria. We recently reported that Chlamydia remodels and recruit two major cytoskeletal components of the host cell- F-actin and Intermediate filaments-to form a dynamic scaffold that provides structural stability to the inclusion. As the inclusion expands, a secreted chlamydial protease progressively modifies the intermediate filaments scaffold, presumably to increase the inclusion's flexibility and accommodate the increased bacterial load. This represents a unique mechanism employed by an intracellular pathogen to support its intracellular niche and may be linked to immune evasion by this pathogen. Here, we discuss the potential consequences of Chlamydia-mediated alteration of host cytoskeletal dynamics on the pathogenesis of chlamydial infections.

Full Text

Duke Authors

Cited Authors

  • Kumar, Y; Valdivia, RH

Published Date

  • 2008

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 175 - 177

PubMed ID

  • 19704885

Pubmed Central ID

  • 19704885

Electronic International Standard Serial Number (EISSN)

  • 1942-0889

Digital Object Identifier (DOI)

  • 10.4161/cib.1.2.7146


  • eng

Conference Location

  • United States