A beta-cyclodextrin based fiber-optic chemical sensor: a fractal analysis.


Journal Article

A fractal analysis is presented for the binding of pyrene in solution to beta-cyclodextrin attached to a fiber-optic chemical sensor. The specific (k(l)) and non-specific binding rate coefficients and the fractal dimension (D(f)) (specific binding case only) both tend to increase as the pyrene concentration in solution increases from 12.4 to 124 ng ml(-1). Predictive relations for the binding rate coefficient (specific as well as non-specific binding) and for D(f) (specific binding case only) as a function of pyrene concentration are provided. These relations fit the calculated k(l) and D(f) values in the pyrene concentration range reasonably well. Fractal analysis data seem to indicate that an increase in the pyrene concentration in solution increases the "ruggedness" or inhomogeneity on the fiber-optic biosensor surface. The fractal analysis provides novel physical insights into the reactions occuring on the fiber-optic chemical surface and should assist in the design of fiber-optic chemical sensors.

Full Text

Duke Authors

Cited Authors

  • Sadana, A; Alarie, JP; Vo-Dinh, T

Published Date

  • October 1995

Published In

Volume / Issue

  • 42 / 10

Start / End Page

  • 1567 - 1574

PubMed ID

  • 18966390

Pubmed Central ID

  • 18966390

Electronic International Standard Serial Number (EISSN)

  • 1873-3573

International Standard Serial Number (ISSN)

  • 0039-9140

Digital Object Identifier (DOI)

  • 10.1016/0039-9140(95)01607-d


  • eng