The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials.

Journal Article (Journal Article;Review)

Antiepileptic drugs (AEDs) have diverse psychotropic profiles. Some AEDs have proven to be efficacious in the treatment of mood disorders, especially bipolar disorder. Others are ineffective as primary treatments but may be useful adjuncts for mood disorders or comorbid conditions. Valproate (acute mania and mixed episodes), carbamazepine (acute mania and mixed episodes), and lamotrigine (maintenance to delay recurrence) have United States Food and Drug Administration indications for the treatment of bipolar disorder. This article provides an overview of data on the use of AEDs in bipolar disorder, including acute mania and depression, prophylaxis, and rapid cycling.

Full Text

Duke Authors

Cited Authors

  • Weisler, RH; Cutler, AJ; Ballenger, JC; Post, RM; Ketter, TA

Published Date

  • October 2006

Published In

Volume / Issue

  • 11 / 10

Start / End Page

  • 788 - 799

PubMed ID

  • 17008822

International Standard Serial Number (ISSN)

  • 1092-8529

Digital Object Identifier (DOI)

  • 10.1017/s1092852900014917


  • eng

Conference Location

  • United States