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Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.

Publication ,  Journal Article
Xie, X; Xia, W; Li, Z; Kuo, H-P; Liu, Y; Li, Z; Ding, Q; Zhang, S; Spohn, B; Yang, Y; Wei, Y; Lang, J-Y; Evans, DB; Chiao, PJ; Hung, M-C ...
Published in: Cancer Cell
July 2007
Published version (DOI) Link to item

Pancreatic cancer is an aggressive malignancy with morbidity rates almost equal to mortality rates because of the current lack of effective treatment options. Here, we describe a targeted approach to treating pancreatic cancer with effective therapeutic efficacy and safety in noninvasive imaging models. We developed a versatile expression vector "VISA" (VP16-GAL4-WPRE integrated systemic amplifier) and a CCKAR (cholecystokinin type A receptor) gene-based, pancreatic-cancer-specific promoter VISA (CCKAR-VISA) composite to target transgene expression in pancreatic tumors in vivo. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR-VISA, exhibited significant antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic orthotopic mouse models of pancreatic tumors with virtually no toxicity.

Duke Scholars

James Abbruzzese
Author James Abbruzzese Medicine, Medical Oncology
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Published In

Cancer Cell

DOI

10.1016/j.ccr.2007.05.009

ISSN

1535-6108

Publication Date

July 2007

Volume

12

Issue

1

Start / End Page

52 / 65

Location

United States

Related Subject Headings

  • Transgenes
  • Receptors, Cholecystokinin
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Models, Biological
  • Mice, Inbred C57BL
  • Mice
  • Animals
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
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Xie, X., Xia, W., Li, Z., Kuo, H.-P., Liu, Y., Ding, Q., … Hung, M.-C. (2007). Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell, 12(1), 52–65. https://doi.org/10.1016/j.ccr.2007.05.009
Xie, Xiaoming, Weiya Xia, Zhongkui Li, Hsu-Ping Kuo, Yuanfang Liu, Zheng Li, Qingqing Ding, et al. “Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.” Cancer Cell 12, no. 1 (July 2007): 52–65. https://doi.org/10.1016/j.ccr.2007.05.009.
Xie X, Xia W, Li Z, Kuo H-P, Liu Y, Ding Q, et al. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell. 2007 Jul;12(1):52–65.
Xie, Xiaoming, et al. “Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.” Cancer Cell, vol. 12, no. 1, July 2007, pp. 52–65. Pubmed, doi:10.1016/j.ccr.2007.05.009.
Xie X, Xia W, Li Z, Kuo H-P, Liu Y, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang J-Y, Evans DB, Chiao PJ, Abbruzzese JL, Hung M-C. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell. 2007 Jul;12(1):52–65.
Journal cover image

Published In

Cancer Cell

DOI

10.1016/j.ccr.2007.05.009

ISSN

1535-6108

Publication Date

July 2007

Volume

12

Issue

1

Start / End Page

52 / 65

Location

United States

Related Subject Headings

  • Transgenes
  • Receptors, Cholecystokinin
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Models, Biological
  • Mice, Inbred C57BL
  • Mice
  • Animals
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology