Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity.
Journal Article (Journal Article)
We examined the effects of all-trans retinoic acid (RA) on alpha(1-->2) fucosyltransferase activity and sensitivity to LAK-mediated cytotoxicity in two rat colon carcinoma cell lines differing by their glycosylation state and their tumorigenic potential. RA induced a decrease in alpha(1-->2) fucosyltransferase activity in the more tumorigenic variant PROb. Fucosyltransferase mRNA levels were not affected by RA treatment in PROb cells, suggesting a posttranscriptional control. This inhibition was accompanied by a decreased expression of fucosylated membrane glycoconjugates and by a significant increase in the sensitivity to LAK-mediated cytotoxicity. REGb cells, which exhibited a very low enzymatic activity and very few fucosylated glycoconjugates, were more sensitive to LAK-lysis than PROb cells and were not affected by RA treatment.
Full Text
Duke Authors
Cited Authors
- Labarrière, N; Piau, JP; Zennadi, R; Blanchardie, P; Denis, M; Lustenberger, P
Published Date
- February 1993
Published In
Volume / Issue
- 29A / 2
Start / End Page
- 140 - 144
PubMed ID
- 8473271
International Standard Serial Number (ISSN)
- 0883-8364
Digital Object Identifier (DOI)
- 10.1007/BF02630945
Language
- eng
Conference Location
- United States