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Immunohistochemistry of the canine vomeronasal organ.

Publication ,  Journal Article
Dennis, JC; Allgier, JG; Desouza, LS; Eward, WC; Morrison, EE
Published in: J Anat
September 2003

The canine's olfactory acuity is legendary, but neither its main olfactory system nor its vomeronasal system has been described in much detail. We used immunohistochemistry on paraffin-embedded sections of male and female adult dog vomeronasal organ (VNO) to characterize the expression of proteins known to be expressed in the VNO of several other mammals. Basal cell bodies were more apparent in each section than in rodent VNO and expressed immunoreactivity to anticytokeratin and antiepidermal growth factor receptor antibodies. The thin layer of neurone cell bodies in the sensory epithelium and axon fascicles in the lamina propria expressed immunoreactivity to neurone cell adhesion molecule, neurone-specific beta tubulin and protein gene product 9.5. Some neurones expressed growth-associated protein 43 (GAP43): and a number of those also expressed neurone-specific beta tubulin-immunoreactivity. Some axon fascicles were double labelled for those two proteins. The G-protein alpha subunits Gi and Go, involved in the signal transduction pathway, showed immunoreactivity in the sensory cell layer. Our results demonstrate that the canine vomeronasal organ contains a population of cells that expresses several neuronal markers. Furthermore, GAP43 immunoreactivity suggests that the sensory epithelium is neurogenic in adult dogs.

Duke Scholars

Published In

J Anat

DOI

ISSN

0021-8782

Publication Date

September 2003

Volume

203

Issue

3

Start / End Page

329 / 338

Location

England

Related Subject Headings

  • Vomeronasal Organ
  • Tubulin
  • Neurons
  • Male
  • Keratins
  • Immunohistochemistry
  • GTP-Binding Protein alpha Subunits, Gi-Go
  • GTP-Binding Protein alpha Subunits
  • GAP-43 Protein
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dennis, J. C., Allgier, J. G., Desouza, L. S., Eward, W. C., & Morrison, E. E. (2003). Immunohistochemistry of the canine vomeronasal organ. J Anat, 203(3), 329–338. https://doi.org/10.1046/j.1469-7580.2003.00190.x
Dennis, J. C., J. G. Allgier, L. S. Desouza, W. C. Eward, and E. E. Morrison. “Immunohistochemistry of the canine vomeronasal organ.J Anat 203, no. 3 (September 2003): 329–38. https://doi.org/10.1046/j.1469-7580.2003.00190.x.
Dennis JC, Allgier JG, Desouza LS, Eward WC, Morrison EE. Immunohistochemistry of the canine vomeronasal organ. J Anat. 2003 Sep;203(3):329–38.
Dennis, J. C., et al. “Immunohistochemistry of the canine vomeronasal organ.J Anat, vol. 203, no. 3, Sept. 2003, pp. 329–38. Pubmed, doi:10.1046/j.1469-7580.2003.00190.x.
Dennis JC, Allgier JG, Desouza LS, Eward WC, Morrison EE. Immunohistochemistry of the canine vomeronasal organ. J Anat. 2003 Sep;203(3):329–338.
Journal cover image

Published In

J Anat

DOI

ISSN

0021-8782

Publication Date

September 2003

Volume

203

Issue

3

Start / End Page

329 / 338

Location

England

Related Subject Headings

  • Vomeronasal Organ
  • Tubulin
  • Neurons
  • Male
  • Keratins
  • Immunohistochemistry
  • GTP-Binding Protein alpha Subunits, Gi-Go
  • GTP-Binding Protein alpha Subunits
  • GAP-43 Protein
  • Female