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Increased cortical excitability with prefrontal high-frequency repetitive transcranial magnetic stimulation in adolescents with treatment-resistant major depressive disorder.

Publication ,  Journal Article
Croarkin, PE; Wall, CA; Nakonezny, PA; Buyukdura, JS; Husain, MM; Sampson, SM; Emslie, GJ; Kozel, FA
Published in: J Child Adolesc Psychopharmacol
February 2012

OBJECTIVE: To examine changes in motor cortical excitability in adolescent subjects receiving 30 sessions of high-frequency prefrontal repetitive transcranial magnetic stimulation (rTMS). METHODS: Eight adolescents with treatment-resistant major depressive disorder (MDD) enrolled in an open augmentation trial of 10 Hz rTMS. Resting motor thresholds were obtained by the visualization of movement method with a maximum likelihood threshold hunting computer algorithm at baseline and after every five sessions of rTMS. Motor threshold was recorded as the percentage of total machine output at each measurement. RESULTS: Motor threshold data from baseline, weeks 2, 4, and 5 were included in a mixed model repeated measure analysis to examine a change in least square mean effect over time. The omnibus effect did not reach statistical significance (F=1.25, p=0.32). However, multiple comparisons from the overall model demonstrated a decrease in the least square mean motor threshold. The mean contrast from baseline to week 5 approached significance (p=0.07). Moreover, a post-hoc analysis with a Wilcoxon signed ranks test demonstrated a significant decrease at week 5 (p=0.03). CONCLUSIONS: This suggests that high-frequency rTMS may increase cortical excitability in adolescents with treatment-resistant MDD.

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Published In

J Child Adolesc Psychopharmacol

DOI

EISSN

1557-8992

Publication Date

February 2012

Volume

22

Issue

1

Start / End Page

56 / 64

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Statistics, Nonparametric
  • Pilot Projects
  • Motor Cortex
  • Likelihood Functions
  • Least-Squares Analysis
  • Humans
  • Female
  • Developmental & Child Psychology
 

Citation

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Croarkin, P. E., Wall, C. A., Nakonezny, P. A., Buyukdura, J. S., Husain, M. M., Sampson, S. M., … Kozel, F. A. (2012). Increased cortical excitability with prefrontal high-frequency repetitive transcranial magnetic stimulation in adolescents with treatment-resistant major depressive disorder. J Child Adolesc Psychopharmacol, 22(1), 56–64. https://doi.org/10.1089/cap.2011.0054
Croarkin, Paul E., Christopher A. Wall, Paul A. Nakonezny, Jeylan S. Buyukdura, Mustafa M. Husain, Shirlene M. Sampson, Graham J. Emslie, and F Andrew Kozel. “Increased cortical excitability with prefrontal high-frequency repetitive transcranial magnetic stimulation in adolescents with treatment-resistant major depressive disorder.J Child Adolesc Psychopharmacol 22, no. 1 (February 2012): 56–64. https://doi.org/10.1089/cap.2011.0054.
Croarkin PE, Wall CA, Nakonezny PA, Buyukdura JS, Husain MM, Sampson SM, et al. Increased cortical excitability with prefrontal high-frequency repetitive transcranial magnetic stimulation in adolescents with treatment-resistant major depressive disorder. J Child Adolesc Psychopharmacol. 2012 Feb;22(1):56–64.
Croarkin, Paul E., et al. “Increased cortical excitability with prefrontal high-frequency repetitive transcranial magnetic stimulation in adolescents with treatment-resistant major depressive disorder.J Child Adolesc Psychopharmacol, vol. 22, no. 1, Feb. 2012, pp. 56–64. Pubmed, doi:10.1089/cap.2011.0054.
Croarkin PE, Wall CA, Nakonezny PA, Buyukdura JS, Husain MM, Sampson SM, Emslie GJ, Kozel FA. Increased cortical excitability with prefrontal high-frequency repetitive transcranial magnetic stimulation in adolescents with treatment-resistant major depressive disorder. J Child Adolesc Psychopharmacol. 2012 Feb;22(1):56–64.
Journal cover image

Published In

J Child Adolesc Psychopharmacol

DOI

EISSN

1557-8992

Publication Date

February 2012

Volume

22

Issue

1

Start / End Page

56 / 64

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Statistics, Nonparametric
  • Pilot Projects
  • Motor Cortex
  • Likelihood Functions
  • Least-Squares Analysis
  • Humans
  • Female
  • Developmental & Child Psychology