Assessing anxious features in depressed outpatients.

Journal Article (Journal Article)

Both the 17-item Hamilton Rating Scale for Depression (HRSD(17)) and 30-item Inventory of Depressive Symptomatology - Clinician-rated (IDS-C(30) ) contain a subscale that assesses anxious symptoms. We used classical test theory and item response theory methods to assess and compare the psychometric properties of the two anxiety subscales (HRSD(ANX) and IDS-C(ANX)) in a large sample (N = 3453) of outpatients with non-psychotic major depressive disorder in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Approximately 48% of evaluable participants had at least one concurrent anxiety disorder by the self-report Psychiatric Diagnostic Screening Questionnaire (PDSQ). The HRSD(ANX) and IDS-C(ANX) were highly correlated (r = 0.75) and both had moderate internal consistency given their limited number of items (HRSD(ANX) Cronbach's alpha = 0.48; IDS-C(ANX) Cronbach's alpha = 0.58). The optimal threshold for ascribing the presence/absence of anxious features was found at a total score of eight or nine for the HRSD(ANX) and seven or eight for the IDS-C(ANX) . It would seem beneficial to delete item 17 (loss of insight) from the HRSD(ANX) as it negatively correlated with the scale's total score. Both the HRSD(ANX) and IDS-C(ANX) subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes.

Full Text

Duke Authors

Cited Authors

  • McClintock, SM; Husain, MM; Bernstein, IH; Wisniewski, SR; Trivedi, MH; Morris, D; Alpert, J; Warden, D; Luther, JF; Kornstein, SG; Biggs, MM; Fava, M; Rush, AJ

Published Date

  • December 2011

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • e69 - e82

PubMed ID

  • 22057975

Pubmed Central ID

  • PMC3708141

Electronic International Standard Serial Number (EISSN)

  • 1557-0657

Digital Object Identifier (DOI)

  • 10.1002/mpr.353


  • eng

Conference Location

  • United States