Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohort.

Journal Article (Journal Article;Multicenter Study)

The demographics and clinical features were compared between those with (29.4%) and without concurrent substance use disorder (SUD) in 2541 outpatients with major depression (MDD) enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater functional impairment (p = 0.048 to <0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities (p = 0.006 and 0.002, respectively).

Full Text

Duke Authors

Cited Authors

  • Davis, LL; Frazier, E; Husain, MM; Warden, D; Trivedi, M; Fava, M; Cassano, P; McGrath, PJ; Balasubramani, GK; Wisniewski, SR; Rush, AJ

Published Date

  • July 2006

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 278 - 285

PubMed ID

  • 16867922

International Standard Serial Number (ISSN)

  • 1055-0496

Digital Object Identifier (DOI)

  • 10.1080/10550490600754317


  • eng

Conference Location

  • England