Cerebral white matter disease in late-onset paranoid psychosis.

Journal Article (Journal Article)

We examined magnetic resonance (MR) scans of the heads of 8 patients with late onset psychosis and 8 aged controls. Although some patients had mild cognitive impairment, none had depression or a history or examination suggesting focal brain disease. Thus, all patients met DSM-III-R criteria for late-onset schizophrenia. All 8 patients showed significant leukoencephalopathy or vascular pathology on MR imaging, and temporoparietal and occipital lesions were especially prominent. Little such pathology was evident on control scans. We suggest that focal brain disease of vascular origin may be associated with late-onset psychosis, and that MR scanning of such cases may provide important clues to pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Breitner, JC; Husain, MM; Figiel, GS; Krishnan, KR; Boyko, OB

Published Date

  • August 1, 1990

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 266 - 274

PubMed ID

  • 2378929

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(90)90582-m


  • eng

Conference Location

  • United States