Sperm morphology as diagnosed by strict criteria: probing the impact of teratozoospermia on fertilization rate and pregnancy outcome in a large in vitro fertilization population.


Journal Article

To investigate the predictive value of sperm morphology assessed by strict criteria on IVF outcome.Retrospective analysis of all IVF cycles (January 1987 to December 1992).All patients were assigned to one of three groups based on sperm morphology: P-pattern (< 4% normal forms), G-pattern (4% to 14% normal forms), and N-pattern (> 14% normal forms). Morphology pattern was related to other semen characteristics and IVF outcome.Despite corrective measures at oocyte insemination, the fertilization rate was significantly different among the three morphology groups, P < G < N. N-pattern sperm produced a mean fertilization rate over 85% regardless of low motility or concentration. In a cohort study, P-pattern cycles produced a lower implantation rate and lower ongoing pregnancy rate, independent of the lower fertilization rate.Strict morphology is an excellent biomarker of sperm fertilizing capacity, independent of motility and concentration. P-pattern sperm may denote a poorer prognosis for establishing a pregnancy, even after a satisfactory fertilization rate is achieved.

Full Text

Duke Authors

Cited Authors

  • Grow, DR; Oehninger, S; Seltman, HJ; Toner, JP; Swanson, RJ; Kruger, TF; Muasher, SJ

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 62 / 3

Start / End Page

  • 559 - 567

PubMed ID

  • 8062953

Pubmed Central ID

  • 8062953

Electronic International Standard Serial Number (EISSN)

  • 1556-5653

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)56946-5


  • eng