Sperm morphology as diagnosed by strict criteria: probing the impact of teratozoospermia on fertilization rate and pregnancy outcome in a large in vitro fertilization population.
Journal Article (Journal Article)
OBJECTIVE: To investigate the predictive value of sperm morphology assessed by strict criteria on IVF outcome. DESIGN: Retrospective analysis of all IVF cycles (January 1987 to December 1992). MAIN OUTCOME MEASURES: All patients were assigned to one of three groups based on sperm morphology: P-pattern (< 4% normal forms), G-pattern (4% to 14% normal forms), and N-pattern (> 14% normal forms). Morphology pattern was related to other semen characteristics and IVF outcome. RESULTS: Despite corrective measures at oocyte insemination, the fertilization rate was significantly different among the three morphology groups, P < G < N. N-pattern sperm produced a mean fertilization rate over 85% regardless of low motility or concentration. In a cohort study, P-pattern cycles produced a lower implantation rate and lower ongoing pregnancy rate, independent of the lower fertilization rate. CONCLUSIONS: Strict morphology is an excellent biomarker of sperm fertilizing capacity, independent of motility and concentration. P-pattern sperm may denote a poorer prognosis for establishing a pregnancy, even after a satisfactory fertilization rate is achieved.
Full Text
Duke Authors
Cited Authors
- Grow, DR; Oehninger, S; Seltman, HJ; Toner, JP; Swanson, RJ; Kruger, TF; Muasher, SJ
Published Date
- September 1, 1994
Published In
Volume / Issue
- 62 / 3
Start / End Page
- 559 - 567
PubMed ID
- 8062953
International Standard Serial Number (ISSN)
- 0015-0282
Digital Object Identifier (DOI)
- 10.1016/s0015-0282(16)56946-5
Language
- eng
Conference Location
- United States