Gonadotropin stimulation protocols in the Norfolk IVF program--1988.

Journal Article (Journal Article)

A standard FSH/hMG stimulation protocol applied to all patients does not yield optimum results. In the Norfolk program it has been found that the determination of FSH/LH ratio on day 3 of the menstrual cycle provides a predictive signal of the likelihood of a good or bad response to a standard protocol. If the FSH is high in relation to LH, the patient will likely be a low responder and/or approaching the menopause. A regime of high-dose pure FSH seems to improve the number of eggs in this group and therefore the pregnancy rate. On the other hand, if the FSH/LH ratio is very low, that is, the patient has a high LH, the patient is generally a high responder and produces many eggs, but in some instances the quality of eggs is suspect, and the pregnancy rate is low in a particular subset of high responders. The use of GnRHa and/or minimal stimulation with FSH or hMG seems to improve the pregnancy rate.

Full Text

Duke Authors

Cited Authors

  • Jones, GS; Muasher, SJ; Liu, HC

Published Date

  • October 1989

Published In

Volume / Issue

  • 33 / 4B

Start / End Page

  • 823 - 825

PubMed ID

  • 2513456

International Standard Serial Number (ISSN)

  • 0022-4731

Digital Object Identifier (DOI)

  • 10.1016/0022-4731(89)90500-1


  • eng

Conference Location

  • England