Ketamine as an adjunct to morphine in the treatment of pain.


Journal Article

A double-blind multidose trial of the addition of ketamine (0-40 mg, i.m., 8 times per day) to intramuscular morphine therapy was undertaken in a 61-year-old man with chronic back pain related to osteoporosis who had received inadequate pain relief from anterior interbody fusion, dorsal column stimulation and morphine alone. The patient reported only mild side effects. Nausea, tiredness and well-being were not significantly influenced by the ketamine dose level. Visual analogue pain scores prior to each dose were not associated with the ketamine dose level, but pain scores 30 min after doses were significantly reduced in a dose-related manner. In addition, the amount of morphine used by the patient was significantly reduced as the ketamine dose increased. This patient experienced substantial benefit from the addition of ketamine to intramuscular morphine therapy.

Full Text

Cited Authors

  • Cherry, DA; Plummer, JL; Gourlay, GK; Coates, KR; Odgers, CL

Published Date

  • July 1995

Published In

Volume / Issue

  • 62 / 1

Start / End Page

  • 119 - 121

PubMed ID

  • 7478701

Pubmed Central ID

  • 7478701

Electronic International Standard Serial Number (EISSN)

  • 1872-6623

International Standard Serial Number (ISSN)

  • 0304-3959

Digital Object Identifier (DOI)

  • 10.1016/0304-3959(95)00010-p


  • eng