Multiple Q-shell ODF reconstruction in Q-ball imaging.

Journal Article (Journal Article)

Q-ball imaging (QBI) is a high angular resolution diffusion imaging (HARDI) technique which has been proven very successful in resolving multiple intravoxel fiber orientations in MR images. The standard computation of the orientation distribution function (ODF, the probability of diffusion in a given direction) from q-ball uses linear radial projection, neglecting the change in the volume element along the ray, thereby resulting in distributions different from the true ODFs. A new technique has been recently proposed that, by considering the solid angle factor, uses the mathematically correct definition of the ODF and results in a dimensionless and normalized ODF expression from a single q-shell. In this paper, we extend this technique in order to exploit HARDI data from multiple q-shells. We consider the more flexible multi-exponential model for the diffusion signal, and show how to efficiently compute the ODFs in constant solid angle. We describe our method and demonstrate its improved performance on both artificial and real HARDI data.

Full Text

Duke Authors

Cited Authors

  • Aganj, I; Lenglet, C; Sapiro, G; Yacoub, E; Ugurbil, K; Harel, N

Published Date

  • January 2009

Published In

  • Medical Image Computing and Computer Assisted Intervention : Miccai ... International Conference on Medical Image Computing and Computer Assisted Intervention

Volume / Issue

  • 12 / Pt 2

Start / End Page

  • 423 - 431

PubMed ID

  • 20426140

Pubmed Central ID

  • PMC4360971

Digital Object Identifier (DOI)

  • 10.1007/978-3-642-04271-3_52


  • eng