A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.

Published

Journal Article

The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin remodeling. The WAVE-associated GTPase activating protein called WRP is implicated in human mental retardation, and WAVE-1 knock-out mice have altered behavior. Neuronal time-lapse imaging, behavioral analyses, and electrophysiological recordings from genetically modified mice were used to show that WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity. Gene targeting experiments in mice demonstrate that WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity. This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior.

Full Text

Duke Authors

Cited Authors

  • Soderling, SH; Guire, ES; Kaech, S; White, J; Zhang, F; Schutz, K; Langeberg, LK; Banker, G; Raber, J; Scott, JD

Published Date

  • January 10, 2007

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 355 - 365

PubMed ID

  • 17215396

Pubmed Central ID

  • 17215396

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.3209-06.2006

Language

  • eng

Conference Location

  • United States