Familial aggregation of melanoma, basal cell carcinoma, and gastric adenocarcinoma.


Journal Article

A family with four cases of melanoma, seven cases of basal cell carcinoma, and two cases of gastric adenocarcinoma, is described. The proband, who had three different primary tumors, died of gastric cancer, as did his father. Four of the proband's six siblings were affected with melanoma or basal cell cancer, as were two of his three children. Both daughters of one melanoma patient developed basal cell cancers. No spouses were affected, the cases were widely separated in time and place, and no unusual exposures were reported. HLA analysis of affected and unaffected first-degree relatives showed no association with antigens previously described in familial melanoma or segregation with a specific HLA haplotype. Although there was no association with HLA phenotype, these results suggest that melanoma, basal cell carcinoma, and gastric adenocarcinoma can be inherited in an autosomally dominant pattern similar to other familial tumor syndromes.

Full Text

Duke Authors

Cited Authors

  • Weston, B; Grufferman, S; Kostyu, D; Burton, CS; Grant, J

Published Date

  • June 1, 1986

Published In

Volume / Issue

  • 57 / 11

Start / End Page

  • 2230 - 2234

PubMed ID

  • 3697921

Pubmed Central ID

  • 3697921

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19860601)57:11<2230::aid-cncr2820571126>3.0.co;2-5


  • eng

Conference Location

  • United States