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Growth hormone-releasing factor stimulation test in depression.

Publication ,  Journal Article
Krishnan, KR; Manepalli, AN; Ritchie, JC; Rayasam, K; Melville, ML; Daughtry, G; Thorner, MO; Rivier, JE; Vale, WW; Nemeroff, CB
Published in: Am J Psychiatry
January 1988

The authors administered the growth hormone-releasing factor (GRF) stimulation test to 19 patients with major depression and 19 age- and sex-matched control subjects to test the hypothesis that a blunted growth hormone (GH) response to clonidine reflects a central alpha 2-adrenergic receptor subsensitivity in depression. GH response to GRF was significantly higher in patients with depression than in control subjects. This group difference was mainly attributable to three of the 19 depressed patients who exhibited markedly high GH responses to GRF. These results suggest that the blunted GH response to clonidine seen in patients with depression is not due to a pituitary defect in GH secretion.

Duke Scholars

Published In

Am J Psychiatry

DOI

ISSN

0002-953X

Publication Date

January 1988

Volume

145

Issue

1

Start / End Page

90 / 92

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, alpha
  • Psychiatry
  • Male
  • Humans
  • Growth Hormone-Releasing Hormone
  • Growth Hormone
  • Female
  • Dextroamphetamine
  • Depressive Disorder
  • Clonidine
 

Citation

APA
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MLA
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Krishnan, K. R., Manepalli, A. N., Ritchie, J. C., Rayasam, K., Melville, M. L., Daughtry, G., … Nemeroff, C. B. (1988). Growth hormone-releasing factor stimulation test in depression. Am J Psychiatry, 145(1), 90–92. https://doi.org/10.1176/ajp.145.1.90
Krishnan, K. R., A. N. Manepalli, J. C. Ritchie, K. Rayasam, M. L. Melville, G. Daughtry, M. O. Thorner, J. E. Rivier, W. W. Vale, and C. B. Nemeroff. “Growth hormone-releasing factor stimulation test in depression.Am J Psychiatry 145, no. 1 (January 1988): 90–92. https://doi.org/10.1176/ajp.145.1.90.
Krishnan KR, Manepalli AN, Ritchie JC, Rayasam K, Melville ML, Daughtry G, et al. Growth hormone-releasing factor stimulation test in depression. Am J Psychiatry. 1988 Jan;145(1):90–2.
Krishnan, K. R., et al. “Growth hormone-releasing factor stimulation test in depression.Am J Psychiatry, vol. 145, no. 1, Jan. 1988, pp. 90–92. Pubmed, doi:10.1176/ajp.145.1.90.
Krishnan KR, Manepalli AN, Ritchie JC, Rayasam K, Melville ML, Daughtry G, Thorner MO, Rivier JE, Vale WW, Nemeroff CB. Growth hormone-releasing factor stimulation test in depression. Am J Psychiatry. 1988 Jan;145(1):90–92.
Journal cover image

Published In

Am J Psychiatry

DOI

ISSN

0002-953X

Publication Date

January 1988

Volume

145

Issue

1

Start / End Page

90 / 92

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, alpha
  • Psychiatry
  • Male
  • Humans
  • Growth Hormone-Releasing Hormone
  • Growth Hormone
  • Female
  • Dextroamphetamine
  • Depressive Disorder
  • Clonidine