Growth hormone-releasing factor stimulation test in depression.
Publication
, Journal Article
Krishnan, KR; Manepalli, AN; Ritchie, JC; Rayasam, K; Melville, ML; Daughtry, G; Thorner, MO; Rivier, JE; Vale, WW; Nemeroff, CB
Published in: Am J Psychiatry
January 1988
The authors administered the growth hormone-releasing factor (GRF) stimulation test to 19 patients with major depression and 19 age- and sex-matched control subjects to test the hypothesis that a blunted growth hormone (GH) response to clonidine reflects a central alpha 2-adrenergic receptor subsensitivity in depression. GH response to GRF was significantly higher in patients with depression than in control subjects. This group difference was mainly attributable to three of the 19 depressed patients who exhibited markedly high GH responses to GRF. These results suggest that the blunted GH response to clonidine seen in patients with depression is not due to a pituitary defect in GH secretion.
Duke Scholars
Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
January 1988
Volume
145
Issue
1
Start / End Page
90 / 92
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha
- Psychiatry
- Male
- Humans
- Growth Hormone-Releasing Hormone
- Growth Hormone
- Female
- Dextroamphetamine
- Depressive Disorder
- Clonidine
Citation
APA
Chicago
ICMJE
MLA
NLM
Krishnan, K. R., Manepalli, A. N., Ritchie, J. C., Rayasam, K., Melville, M. L., Daughtry, G., … Nemeroff, C. B. (1988). Growth hormone-releasing factor stimulation test in depression. Am J Psychiatry, 145(1), 90–92. https://doi.org/10.1176/ajp.145.1.90
Krishnan, K. R., A. N. Manepalli, J. C. Ritchie, K. Rayasam, M. L. Melville, G. Daughtry, M. O. Thorner, J. E. Rivier, W. W. Vale, and C. B. Nemeroff. “Growth hormone-releasing factor stimulation test in depression.” Am J Psychiatry 145, no. 1 (January 1988): 90–92. https://doi.org/10.1176/ajp.145.1.90.
Krishnan KR, Manepalli AN, Ritchie JC, Rayasam K, Melville ML, Daughtry G, et al. Growth hormone-releasing factor stimulation test in depression. Am J Psychiatry. 1988 Jan;145(1):90–2.
Krishnan, K. R., et al. “Growth hormone-releasing factor stimulation test in depression.” Am J Psychiatry, vol. 145, no. 1, Jan. 1988, pp. 90–92. Pubmed, doi:10.1176/ajp.145.1.90.
Krishnan KR, Manepalli AN, Ritchie JC, Rayasam K, Melville ML, Daughtry G, Thorner MO, Rivier JE, Vale WW, Nemeroff CB. Growth hormone-releasing factor stimulation test in depression. Am J Psychiatry. 1988 Jan;145(1):90–92.
Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
January 1988
Volume
145
Issue
1
Start / End Page
90 / 92
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha
- Psychiatry
- Male
- Humans
- Growth Hormone-Releasing Hormone
- Growth Hormone
- Female
- Dextroamphetamine
- Depressive Disorder
- Clonidine