Growth hormone-releasing factor stimulation test in depression.

Journal Article (Journal Article)

The authors administered the growth hormone-releasing factor (GRF) stimulation test to 19 patients with major depression and 19 age- and sex-matched control subjects to test the hypothesis that a blunted growth hormone (GH) response to clonidine reflects a central alpha 2-adrenergic receptor subsensitivity in depression. GH response to GRF was significantly higher in patients with depression than in control subjects. This group difference was mainly attributable to three of the 19 depressed patients who exhibited markedly high GH responses to GRF. These results suggest that the blunted GH response to clonidine seen in patients with depression is not due to a pituitary defect in GH secretion.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Manepalli, AN; Ritchie, JC; Rayasam, K; Melville, ML; Daughtry, G; Thorner, MO; Rivier, JE; Vale, WW; Nemeroff, CB

Published Date

  • January 1988

Published In

Volume / Issue

  • 145 / 1

Start / End Page

  • 90 - 92

PubMed ID

  • 2827532

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.145.1.90


  • eng

Conference Location

  • United States