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Meta-analysis identifies common variants associated with body mass index in east Asians.

Publication ,  Journal Article
Wen, W; Cho, Y-S; Zheng, W; Dorajoo, R; Kato, N; Qi, L; Chen, C-H; Delahanty, RJ; Okada, Y; Tabara, Y; Gu, D; Zhu, D; Haiman, CA; Mo, Z ...
Published in: Nat Genet
February 19, 2012

Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 × 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 × 10(-7). Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

February 19, 2012

Volume

44

Issue

3

Start / End Page

307 / 311

Location

United States

Related Subject Headings

  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Obesity
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Developmental Biology
  • Body Mass Index
  • Asian People
 

Citation

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Wen, W., Cho, Y.-S., Zheng, W., Dorajoo, R., Kato, N., Qi, L., … Shu, X.-O. (2012). Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet, 44(3), 307–311. https://doi.org/10.1038/ng.1087
Wen, Wanqing, Yoon-Shin Cho, Wei Zheng, Rajkumar Dorajoo, Norihiro Kato, Lu Qi, Chien-Hsiun Chen, et al. “Meta-analysis identifies common variants associated with body mass index in east Asians.Nat Genet 44, no. 3 (February 19, 2012): 307–11. https://doi.org/10.1038/ng.1087.
Wen W, Cho Y-S, Zheng W, Dorajoo R, Kato N, Qi L, et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet. 2012 Feb 19;44(3):307–11.
Wen, Wanqing, et al. “Meta-analysis identifies common variants associated with body mass index in east Asians.Nat Genet, vol. 44, no. 3, Feb. 2012, pp. 307–11. Pubmed, doi:10.1038/ng.1087.
Wen W, Cho Y-S, Zheng W, Dorajoo R, Kato N, Qi L, Chen C-H, Delahanty RJ, Okada Y, Tabara Y, Gu D, Zhu D, Haiman CA, Mo Z, Gao Y-T, Saw S-M, Go M-J, Takeuchi F, Chang L-C, Kokubo Y, Liang J, Hao M, Le Marchand L, Zhang Y, Hu Y, Wong T-Y, Long J, Han B-G, Kubo M, Yamamoto K, Su M-H, Miki T, Henderson BE, Song H, Tan A, He J, Ng DP-K, Cai Q, Tsunoda T, Tsai F-J, Iwai N, Chen GK, Shi J, Xu J, Sim X, Xiang Y-B, Maeda S, Ong RTH, Li C, Nakamura Y, Aung T, Kamatani N, Liu J-J, Lu W, Yokota M, Seielstad M, Fann CSJ, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Wu J-Y, Lee J-Y, Hu FB, Tanaka T, Tai ES, Shu X-O. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet. 2012 Feb 19;44(3):307–311.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

February 19, 2012

Volume

44

Issue

3

Start / End Page

307 / 311

Location

United States

Related Subject Headings

  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Obesity
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Developmental Biology
  • Body Mass Index
  • Asian People