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Patient-specific radiation dose and cancer risk estimation in pediatric chest CT: A study in 30 patients

Publication ,  Conference
Li, X; Samei, E; Segars, WP; Sturgeon, GM; Colsher, JG; Frush, DP
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
December 1, 2010

Radiation-dose awareness and optimization in CT can greatly benefit from a dose- reporting system that provides radiation dose and cancer risk estimates specific to each patient and each CT examination. Recently, we reported a method for estimating patient- specific dose from pediatric chest CT. The purpose of this study is to extend that effort to patient-specific risk estimation and to a population of pediatric CT patients. Our study included thirty pediatric CT patients (16 males and 14 females; 0-16 years old), for whom full-body computer models were recently created based on the patients' clinical CT data. Using a validated Monte Carlo program, organ dose received by the thirty patients from a chest scan protocol (LightSpeed VCT, 120 kVp, 1.375 pitch, 40-mm collimation, pediatric body scan field-of-view) was simulated and used to estimate patient-specific effective dose. Risks of cancer incidence were calculated for radiosensitive organs using gender-, age-, and tissue-specific risk coefficients and were used to derive patient- specific effective risk. The thirty patients had normalized effective dose of 3.7-10.4 mSv/l00 mAs and normalized effective risk of 0.5-5.8 cases/1000 exposed persons/100 mAs. Normalized lung dose and risk of lung cancer correlated strongly with average chest diameter (correlation coefficient: r = -0.98 to -0.99). Normalized effective risk also correlated strongly with average chest diameter (r = -0.97 to -0.98). These strong correlations can be used to estimate patient-specific dose and risk prior to or after an imaging study to potentially guide healthcare providers in justifying CT examinations and to guide individualized protocol design and optimization. © 2010 SPIE.

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

ISBN

9780819480231

Publication Date

December 1, 2010

Volume

7622

Issue

PART 1
 

Citation

APA
Chicago
ICMJE
MLA
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Li, X., Samei, E., Segars, W. P., Sturgeon, G. M., Colsher, J. G., & Frush, D. P. (2010). Patient-specific radiation dose and cancer risk estimation in pediatric chest CT: A study in 30 patients. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7622). https://doi.org/10.1117/12.845491
Li, X., E. Samei, W. P. Segars, G. M. Sturgeon, J. G. Colsher, and D. P. Frush. “Patient-specific radiation dose and cancer risk estimation in pediatric chest CT: A study in 30 patients.” In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 7622, 2010. https://doi.org/10.1117/12.845491.
Li X, Samei E, Segars WP, Sturgeon GM, Colsher JG, Frush DP. Patient-specific radiation dose and cancer risk estimation in pediatric chest CT: A study in 30 patients. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2010.
Li, X., et al. “Patient-specific radiation dose and cancer risk estimation in pediatric chest CT: A study in 30 patients.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7622, no. PART 1, 2010. Scopus, doi:10.1117/12.845491.
Li X, Samei E, Segars WP, Sturgeon GM, Colsher JG, Frush DP. Patient-specific radiation dose and cancer risk estimation in pediatric chest CT: A study in 30 patients. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2010.
Journal cover image

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

ISBN

9780819480231

Publication Date

December 1, 2010

Volume

7622

Issue

PART 1