Design and testing of an interpolating mixing architecture for electrowetting-based droplet-on-chip chemical dilution

Published

Conference Paper

© 2003 IEEE. An on-chip dilution scheme for an electrowetting based microfluidic system is presented in this paper. The dilution scheme uses the mixing and splitting of two droplets of different concentrations to result in an intermediate concentration, as the fundamental operation. A range of dilution factors can be obtained repeating the simple two-droplet mixing and splitting cycles, in various combinations. The accuracy of the dilution scheme primarily depends on two factors-variation in droplet volume during dispensing and splitting, and homogenous mixing. The proposed on-chip dilution architecture was tested for the dilution factors of 2, 4 and 8, using a red food dye as the sample solution and 0.1M KCl solution as the buffer. The concentrations were measured using an optical absorbance measurement system, consisting of an LED and photodiode. The error in the dilution factor was found to be ∼15% for a dilution factor of 4 and ∼25% for a dilution factor of 8. Droplet volume variations in dispensing and splitting contribute to ∼80% of this error.

Full Text

Duke Authors

Cited Authors

  • Ren, H; Srinivasan, V; Fair, RB

Published Date

  • January 1, 2003

Published In

  • Transducers 2003 12th International Conference on Solid State Sensors, Actuators and Microsystems, Digest of Technical Papers

Volume / Issue

  • 1 /

Start / End Page

  • 619 - 622

International Standard Book Number 10 (ISBN-10)

  • 0780377311

International Standard Book Number 13 (ISBN-13)

  • 9780780377318

Digital Object Identifier (DOI)

  • 10.1109/SENSOR.2003.1215549

Citation Source

  • Scopus