Effect of aminophylline on coronary reactive and functional hyperaemic response in conscious dogs.


Journal Article

This study was undertaken to determine whether adenosine release from myocardial cells plays a role in coronary reactive and functional vasomotion. Reactive hyperaemic blood flow responses to 10 s complete occlusions and 400 ms diastolic occlusions of the left circumflex coronary artery and to the vasomotor responses to the increased cardiac demand following ventricular extra-activation were examined in a chronic, heart-blocked dog preparation during a control period and following intravenous bolus administration of aminophylline (5 mg X kg-1). Aminophylline administration resulted in a 19% decrease in the blood flow debt repayment ratio of 10 s reactive hyperaemic responses compared with the control period. However, administration of aminophylline had no effect on the coronary vascular response to 400 ms diastolic occlusions or to ventricular extra-activations. These observations indicate that adenosine may play a role in the coronary vascular response to prolonged interventions but that other factors, as yet unidentified, may be implicated in the beat-to-beat regulation of coronary vascular resistance.

Full Text

Duke Authors

Cited Authors

  • Radford, MJ; McHale, PA; Sadick, N; Schwartz, GG; Greenfield, JC

Published Date

  • June 1, 1984

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 377 - 383

PubMed ID

  • 6744357

Pubmed Central ID

  • 6744357

International Standard Serial Number (ISSN)

  • 0008-6363

Digital Object Identifier (DOI)

  • 10.1093/cvr/18.6.377


  • eng

Conference Location

  • England