agr-Amanitin Tolerance in Mycophagous Drosophila.


Journal Article

Six species of Drosophila were tested for tolerance to the mushroom toxin alpha-amanitin, a potent inhibitor of RNA polymerase II. Three nonmycophagous species-D. melanogaster, D. immigrans, and D. pseudoobscura-showed very low survival and long development times in the presence of amanitin. Three mycophagous species-D. putrida, D. recens, and D. tripunctata-showed little or no sensitivity. Analysis in vitro indicated that this tolerance is not based on alteration of the molecular structure of RNA polymerase II.

Full Text

Duke Authors

Cited Authors

  • Jaenike, J; Grimaldi, DA; Sluder, AE; Greenleaf, AL

Published Date

  • July 8, 1983

Published In

Volume / Issue

  • 221 / 4606

Start / End Page

  • 165 - 167

PubMed ID

  • 17769215

Pubmed Central ID

  • 17769215

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.221.4606.165


  • eng

Conference Location

  • United States