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Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.

Publication ,  Journal Article
Velez, DR; Hulme, WF; Myers, JL; Stryjewski, ME; Abbate, E; Estevan, R; Patillo, SG; Gilbert, JR; Hamilton, CD; Scott, WK
Published in: Int J Tuberc Lung Dis
September 2009

SETTING: Host defense factors may influence the development of active tuberculosis (TB). OBJECTIVE: To test variants in solute carrier family 11A, member 1 (SLC11A1), for an association with TB. METHODS: A mixed case-control study of TB cases, relatives or close contact controls, consisting of 474 African-Americans (243 families) and 381 Caucasians (192 families), examined 13 SLC11A1 polymorphisms for association with pulmonary TB using generalized estimating equations adjusting for age and sex. RESULTS: Two associations were observed in Caucasians (rs3731863, P = 0.03, and rs17221959, P = 0.04) and one in African-Americans (rs3731865, P = 0.05). Multilocus analyses between polymorphisms in SLC11A1 and 11 TB candidate genes detected interactions between SLC11A1 and inducible nitric oxide synthase (NOS2A) in Caucasians (rs3731863 [SLC11A1] x rs8073782 [NOS2A], P = 0.009; rs3731863 [SLC11A1] x rs17722851 [NOS2A], P = 0.007) and toll-like receptor 2 (TLR2) in African-Americans (rs3731865 [SLC11A1] x rs1816702, P = 0.005). CONCLUSIONS: No association was detected with 5'(GT)(n) promoter polymorphism previously associated with lower SLC11A1 expression, rs17235409 (D543N), or rs17235416 (3' TGTG insertion/deletion polymorphism). SLC11A1 polymorphism rs3731865 was associated with TB in African-Americans, consistent with previous findings in West Africans. These results suggest that variants in SLC11A1 increase susceptibility to pulmonary TB and interact with other variants that differ by race.

Duke Scholars

Published In

Int J Tuberc Lung Dis

EISSN

1815-7920

Publication Date

September 2009

Volume

13

Issue

9

Start / End Page

1068 / 1076

Location

France

Related Subject Headings

  • Young Adult
  • White People
  • Tuberculosis
  • Toll-Like Receptor 2
  • Polymorphism, Single Nucleotide
  • Pedigree
  • Odds Ratio
  • North Carolina
  • Nitric Oxide Synthase Type II
  • Middle Aged
 

Citation

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MLA
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Velez, D. R., Hulme, W. F., Myers, J. L., Stryjewski, M. E., Abbate, E., Estevan, R., … Scott, W. K. (2009). Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Int J Tuberc Lung Dis, 13(9), 1068–1076.
Velez, D. R., W. F. Hulme, J. L. Myers, M. E. Stryjewski, E. Abbate, R. Estevan, S. G. Patillo, J. R. Gilbert, C. D. Hamilton, and W. K. Scott. “Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.Int J Tuberc Lung Dis 13, no. 9 (September 2009): 1068–76.
Velez DR, Hulme WF, Myers JL, Stryjewski ME, Abbate E, Estevan R, et al. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Int J Tuberc Lung Dis. 2009 Sep;13(9):1068–76.
Velez, D. R., et al. “Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.Int J Tuberc Lung Dis, vol. 13, no. 9, Sept. 2009, pp. 1068–76.
Velez DR, Hulme WF, Myers JL, Stryjewski ME, Abbate E, Estevan R, Patillo SG, Gilbert JR, Hamilton CD, Scott WK. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Int J Tuberc Lung Dis. 2009 Sep;13(9):1068–1076.

Published In

Int J Tuberc Lung Dis

EISSN

1815-7920

Publication Date

September 2009

Volume

13

Issue

9

Start / End Page

1068 / 1076

Location

France

Related Subject Headings

  • Young Adult
  • White People
  • Tuberculosis
  • Toll-Like Receptor 2
  • Polymorphism, Single Nucleotide
  • Pedigree
  • Odds Ratio
  • North Carolina
  • Nitric Oxide Synthase Type II
  • Middle Aged