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Risk of exogenous estrogen therapy and endometrial cancer.

Publication ,  Journal Article
Jelovsek, FR; Hammond, CB; Woodard, BH; Draffin, R; Lee, KL; Creasman, WT; Parker, RT
Published in: Am J Obstet Gynecol
May 1, 1980

A retrospective study was carried out on 431 patients with endometrial cancer and 431 control subjects matched as to age, race, and parity. They were seen at Duke University Medical Center from 1940 to 1975. The study was performed in order to evaluate the risk of exogenous estrogen therapy and the development of adenocarcinoma of the endometrium. The overall risk was 2.38, with certain subgroups demonstrating different degrees of risk. Increased risk was associated with estrogen therapy of longer than 5 years' duration in white patients. The risk also was confined to Stage I, grade 1 lesions and more superficial myometrial invasion. Five-year survival for patients who used estrogen replacement and had Stage I, grade 1 lesions was 94.7%. The risks associated with exogenous estrogens are real but should be considered in a risk/benefit context when prescribing for the needs of an individual patient.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

May 1, 1980

Volume

137

Issue

1

Start / End Page

85 / 91

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Time Factors
  • Statistics as Topic
  • Risk
  • Retrospective Studies
  • Racial Groups
  • Parity
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Humans
 

Citation

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Jelovsek, F. R., Hammond, C. B., Woodard, B. H., Draffin, R., Lee, K. L., Creasman, W. T., & Parker, R. T. (1980). Risk of exogenous estrogen therapy and endometrial cancer. Am J Obstet Gynecol, 137(1), 85–91. https://doi.org/10.1016/0002-9378(80)90390-7
Jelovsek, F. R., C. B. Hammond, B. H. Woodard, R. Draffin, K. L. Lee, W. T. Creasman, and R. T. Parker. “Risk of exogenous estrogen therapy and endometrial cancer.Am J Obstet Gynecol 137, no. 1 (May 1, 1980): 85–91. https://doi.org/10.1016/0002-9378(80)90390-7.
Jelovsek FR, Hammond CB, Woodard BH, Draffin R, Lee KL, Creasman WT, et al. Risk of exogenous estrogen therapy and endometrial cancer. Am J Obstet Gynecol. 1980 May 1;137(1):85–91.
Jelovsek, F. R., et al. “Risk of exogenous estrogen therapy and endometrial cancer.Am J Obstet Gynecol, vol. 137, no. 1, May 1980, pp. 85–91. Pubmed, doi:10.1016/0002-9378(80)90390-7.
Jelovsek FR, Hammond CB, Woodard BH, Draffin R, Lee KL, Creasman WT, Parker RT. Risk of exogenous estrogen therapy and endometrial cancer. Am J Obstet Gynecol. 1980 May 1;137(1):85–91.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

May 1, 1980

Volume

137

Issue

1

Start / End Page

85 / 91

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Time Factors
  • Statistics as Topic
  • Risk
  • Retrospective Studies
  • Racial Groups
  • Parity
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Humans