Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.

Published

Journal Article

The addition of apoprotein E isolated from human very low density lipoproteins to both rat lymph chylomicrons and a triglyceride emulsion significantly increased the hepatic uptake of these particles in a nonrecycling isolated rat liver perfusion system. The cleared triglyceride was removed without apparent hydrolysis by the hepatocyte. When lymph chylomicrons were loaded with both Apo E and Apo C proteins by exposure to rat plasma, no increment in hepatic clearance was observed. Sequential evalutions of the influence of the C apoproteins on the hepatic clearance of both emulsions and chylomicrons revealed that the CIII (CIII-1) protein had a pronounced inhibitory effect on hepatic removal. The inhibition was observed for both Apo E-enriched chylomicrons and those containing little of this apoprotein.

Full Text

Duke Authors

Cited Authors

  • Shelburne, F; Hanks, J; Meyers, W; Quarfordt, S

Published Date

  • March 1, 1980

Published In

Volume / Issue

  • 65 / 3

Start / End Page

  • 652 - 658

PubMed ID

  • 7354132

Pubmed Central ID

  • 7354132

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI109710

Language

  • eng

Conference Location

  • United States