Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants.


Journal Article (Review)

We held an international consensus conference on frontotemporal dementia, behavioral disturbances, and parkinsonism linked to chromosome 17 to determine whether these are homogeneous or heterogeneous disorders, to agree on terminology, and to develop strategies for further research. The group identified 13 kindreds with sufficient evidence for linkage, finding in common to all a critical 2 cM between markers D17S791 and D17S800. There was agreement that (1) despite previous descriptions that have emphasized one or another clinical or neuropathological feature, the kindreds share clinical and neuropathological features; (2) until more specific information about the genetic defects becomes available, this disorder is best termed frontotemporal dementia and parkinsonism linked to chromosome 17; and (3) further research will be enhanced by identifying the gene or genes responsible for this disorder, detecting additional cases within known families and, in new families, correlating mutations with phenotypes and more fully delineating the clinical, neuropsychological, and neuropathological characteristics of this disorder.

Full Text

Cited Authors

  • Foster, NL; Wilhelmsen, K; Sima, AA; Jones, MZ; D'Amato, CJ; Gilman, S

Published Date

  • June 1997

Published In

Volume / Issue

  • 41 / 6

Start / End Page

  • 706 - 715

PubMed ID

  • 9189031

Pubmed Central ID

  • 9189031

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.410410606


  • eng

Conference Location

  • United States