Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.

Published

Journal Article

PRIM2, encoding a subunit of primase involved in DNA replication and transcription, is expressed in the placenta and is crucial for mammalian development and growth. Its role in placental function is not well understood. Recently, PRIM2 was reported as imprinted in human white blood cells (WBC). We report here our failure to confirm imprinting of the PRIM2 locus in human placenta or WBC. The discordance between our results and those of others are likely due to an incorrectly annotated PRIM2 pseudogene found in the human genome database.

Full Text

Duke Authors

Cited Authors

  • Chung, J; Tsai, S; James, AH; Thames, BH; Shytle, S; Piedrahita, JA

Published Date

  • May 2012

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 429 - 431

PubMed ID

  • 22437878

Pubmed Central ID

  • 22437878

Electronic International Standard Serial Number (EISSN)

  • 1559-2308

Digital Object Identifier (DOI)

  • 10.4161/epi.19777

Language

  • eng

Conference Location

  • United States