Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.
Publication
, Journal Article
Chung, J; Tsai, S; James, AH; Thames, BH; Shytle, S; Piedrahita, JA
Published in: Epigenetics
May 2012
PRIM2, encoding a subunit of primase involved in DNA replication and transcription, is expressed in the placenta and is crucial for mammalian development and growth. Its role in placental function is not well understood. Recently, PRIM2 was reported as imprinted in human white blood cells (WBC). We report here our failure to confirm imprinting of the PRIM2 locus in human placenta or WBC. The discordance between our results and those of others are likely due to an incorrectly annotated PRIM2 pseudogene found in the human genome database.
Duke Scholars
Published In
Epigenetics
DOI
EISSN
1559-2308
Publication Date
May 2012
Volume
7
Issue
5
Start / End Page
429 / 431
Location
United States
Related Subject Headings
- Transcription, Genetic
- RNA, Messenger
- Pseudogenes
- Pregnancy
- Polymorphism, Single Nucleotide
- Placenta
- Molecular Sequence Annotation
- Leukocytes
- Humans
- Heterozygote
Citation
APA
Chicago
ICMJE
MLA
NLM
Chung, J., Tsai, S., James, A. H., Thames, B. H., Shytle, S., & Piedrahita, J. A. (2012). Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. Epigenetics, 7(5), 429–431. https://doi.org/10.4161/epi.19777
Chung, Jaewook, Shengdar Tsai, Andra H. James, Betty H. Thames, Stephanie Shytle, and Jorge A. Piedrahita. “Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.” Epigenetics 7, no. 5 (May 2012): 429–31. https://doi.org/10.4161/epi.19777.
Chung J, Tsai S, James AH, Thames BH, Shytle S, Piedrahita JA. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. Epigenetics. 2012 May;7(5):429–31.
Chung, Jaewook, et al. “Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.” Epigenetics, vol. 7, no. 5, May 2012, pp. 429–31. Pubmed, doi:10.4161/epi.19777.
Chung J, Tsai S, James AH, Thames BH, Shytle S, Piedrahita JA. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. Epigenetics. 2012 May;7(5):429–431.
Published In
Epigenetics
DOI
EISSN
1559-2308
Publication Date
May 2012
Volume
7
Issue
5
Start / End Page
429 / 431
Location
United States
Related Subject Headings
- Transcription, Genetic
- RNA, Messenger
- Pseudogenes
- Pregnancy
- Polymorphism, Single Nucleotide
- Placenta
- Molecular Sequence Annotation
- Leukocytes
- Humans
- Heterozygote