Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.

Published

Journal Article

The placenta plays an important role as a regulator of fetal nutrition and growth throughout development and placental factors contribute to gestational abnormalities such as preeclampsia. This study describes the genome-wide gene expression profiles of a large (n = 60) set of human placentas in order to uncover gene expression patterns associated with preeclampsia. In addition to confirming changes in expression of soluble factors associated with preeclampsia such as sFLT1 (soluble fms-like tyrosine kinase-1), sENG (soluble endoglin), and INHA (inhibin alpha), we also find changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeclampsia. Notably, we also find evidence of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases.

Full Text

Duke Authors

Cited Authors

  • Tsai, S; Hardison, NE; James, AH; Motsinger-Reif, AA; Bischoff, SR; Thames, BH; Piedrahita, JA

Published Date

  • February 2011

Published In

Volume / Issue

  • 32 / 2

Start / End Page

  • 175 - 182

PubMed ID

  • 21183218

Pubmed Central ID

  • 21183218

Electronic International Standard Serial Number (EISSN)

  • 1532-3102

Digital Object Identifier (DOI)

  • 10.1016/j.placenta.2010.11.014

Language

  • eng

Conference Location

  • Netherlands