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Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.

Publication ,  Journal Article
Tsai, S; Hardison, NE; James, AH; Motsinger-Reif, AA; Bischoff, SR; Thames, BH; Piedrahita, JA
Published in: Placenta
February 2011

The placenta plays an important role as a regulator of fetal nutrition and growth throughout development and placental factors contribute to gestational abnormalities such as preeclampsia. This study describes the genome-wide gene expression profiles of a large (n = 60) set of human placentas in order to uncover gene expression patterns associated with preeclampsia. In addition to confirming changes in expression of soluble factors associated with preeclampsia such as sFLT1 (soluble fms-like tyrosine kinase-1), sENG (soluble endoglin), and INHA (inhibin alpha), we also find changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeclampsia. Notably, we also find evidence of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases.

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Published In

Placenta

DOI

EISSN

1532-3102

Publication Date

February 2011

Volume

32

Issue

2

Start / End Page

175 / 182

Location

Netherlands

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-1
  • Up-Regulation
  • Trophoblasts
  • Receptors, Cell Surface
  • Protein Array Analysis
  • Pregnancy
  • Pre-Eclampsia
  • Obstetrics & Reproductive Medicine
  • Male
  • Inhibins
 

Citation

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Tsai, S., Hardison, N. E., James, A. H., Motsinger-Reif, A. A., Bischoff, S. R., Thames, B. H., & Piedrahita, J. A. (2011). Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. Placenta, 32(2), 175–182. https://doi.org/10.1016/j.placenta.2010.11.014
Tsai, S., N. E. Hardison, A. H. James, A. A. Motsinger-Reif, S. R. Bischoff, B. H. Thames, and J. A. Piedrahita. “Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.Placenta 32, no. 2 (February 2011): 175–82. https://doi.org/10.1016/j.placenta.2010.11.014.
Tsai S, Hardison NE, James AH, Motsinger-Reif AA, Bischoff SR, Thames BH, et al. Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. Placenta. 2011 Feb;32(2):175–82.
Tsai, S., et al. “Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.Placenta, vol. 32, no. 2, Feb. 2011, pp. 175–82. Pubmed, doi:10.1016/j.placenta.2010.11.014.
Tsai S, Hardison NE, James AH, Motsinger-Reif AA, Bischoff SR, Thames BH, Piedrahita JA. Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. Placenta. 2011 Feb;32(2):175–182.
Journal cover image

Published In

Placenta

DOI

EISSN

1532-3102

Publication Date

February 2011

Volume

32

Issue

2

Start / End Page

175 / 182

Location

Netherlands

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-1
  • Up-Regulation
  • Trophoblasts
  • Receptors, Cell Surface
  • Protein Array Analysis
  • Pregnancy
  • Pre-Eclampsia
  • Obstetrics & Reproductive Medicine
  • Male
  • Inhibins