Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology.

Journal Article (Journal Article)

The continuing education course "Non-Invasive Imaging as a Problem-Solving Tool and Translational Biomarker Strategy in Toxicologic Pathology" provided a thorough overview of commonly used imaging modalities and the logistics required for integration of small animal imaging into toxicologic pathology. Non-invasive imaging (NIN) is gaining acceptance as an important modality in toxicologic pathology. This technology allows nonterminal, time-course evaluation of functional and morphologic endpoints and can be used to translate biomarkers between preclinical animal models and human patients. NIN can support drug development as well as basic research in academic or industrial environments. An initial overview of theoretical principles was followed by focused presentations on magnetic resonance imaging (MRI)/magnetic resonance microscopy (MRM), positron emission tomography (PET)/single proton emission computed tomography (SPECT), ultrasonography (US, primarily focused on echocardiography), optical (bioluminescent) imaging, and computed tomography (CT). The choice of imaging modality will depend on the research question and the needed resolution.

Full Text

Duke Authors

Cited Authors

  • Peterson, RA; Gabrielson, KL; Allan Johnson, G; Pomper, MG; Coatney, RW; Winkelmann, CT

Published Date

  • January 2011

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 267 - 272

PubMed ID

  • 21147931

Pubmed Central ID

  • PMC3519422

Electronic International Standard Serial Number (EISSN)

  • 1533-1601

Digital Object Identifier (DOI)

  • 10.1177/0192623310390392


  • eng

Conference Location

  • United States