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Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology.

Publication ,  Journal Article
Peterson, RA; Gabrielson, KL; Allan Johnson, G; Pomper, MG; Coatney, RW; Winkelmann, CT
Published in: Toxicol Pathol
January 2011

The continuing education course "Non-Invasive Imaging as a Problem-Solving Tool and Translational Biomarker Strategy in Toxicologic Pathology" provided a thorough overview of commonly used imaging modalities and the logistics required for integration of small animal imaging into toxicologic pathology. Non-invasive imaging (NIN) is gaining acceptance as an important modality in toxicologic pathology. This technology allows nonterminal, time-course evaluation of functional and morphologic endpoints and can be used to translate biomarkers between preclinical animal models and human patients. NIN can support drug development as well as basic research in academic or industrial environments. An initial overview of theoretical principles was followed by focused presentations on magnetic resonance imaging (MRI)/magnetic resonance microscopy (MRM), positron emission tomography (PET)/single proton emission computed tomography (SPECT), ultrasonography (US, primarily focused on echocardiography), optical (bioluminescent) imaging, and computed tomography (CT). The choice of imaging modality will depend on the research question and the needed resolution.

Duke Scholars

Published In

Toxicol Pathol

DOI

EISSN

1533-1601

Publication Date

January 2011

Volume

39

Issue

1

Start / End Page

267 / 272

Location

United States

Related Subject Headings

  • Toxicology
  • Toxicology
  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Positron-Emission Tomography
  • Pathology
  • Neurotoxicity Syndromes
  • Nervous System Diseases
  • Models, Animal
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Peterson, R. A., Gabrielson, K. L., Allan Johnson, G., Pomper, M. G., Coatney, R. W., & Winkelmann, C. T. (2011). Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology. Toxicol Pathol, 39(1), 267–272. https://doi.org/10.1177/0192623310390392
Peterson, Richard A., Kathy L. Gabrielson, G. Allan Johnson, Martin G. Pomper, Robert W. Coatney, and Christopher T. Winkelmann. “Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology.Toxicol Pathol 39, no. 1 (January 2011): 267–72. https://doi.org/10.1177/0192623310390392.
Peterson RA, Gabrielson KL, Allan Johnson G, Pomper MG, Coatney RW, Winkelmann CT. Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology. Toxicol Pathol. 2011 Jan;39(1):267–72.
Peterson, Richard A., et al. “Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology.Toxicol Pathol, vol. 39, no. 1, Jan. 2011, pp. 267–72. Pubmed, doi:10.1177/0192623310390392.
Peterson RA, Gabrielson KL, Allan Johnson G, Pomper MG, Coatney RW, Winkelmann CT. Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology. Toxicol Pathol. 2011 Jan;39(1):267–272.
Journal cover image

Published In

Toxicol Pathol

DOI

EISSN

1533-1601

Publication Date

January 2011

Volume

39

Issue

1

Start / End Page

267 / 272

Location

United States

Related Subject Headings

  • Toxicology
  • Toxicology
  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Positron-Emission Tomography
  • Pathology
  • Neurotoxicity Syndromes
  • Nervous System Diseases
  • Models, Animal
  • Magnetic Resonance Imaging