Evidence for a 4-dose vaccine schedule for human rabies post-exposure prophylaxis in previously non-vaccinated individuals.

Journal Article (Journal Article;Review)

After exposure, human rabies is preventable by prompt application of post-exposure prophylaxis. Historically, the total number of rabies vaccine doses administered during human prophylaxis has decreased, as modern biologics have improved and scientific knowledge has grown. A review of the literature on rabies virus pathogenesis, experimental animal studies, clinical trials, epidemiological surveillance, and economic analyses was conducted to determine the potential utility of reducing the current 5-dose intramuscular series of human rabies vaccine administered in the United States. Based upon the available evidence, a reduced schedule of cell-culture rabies vaccine, administered on days 0, 3, 7, and 14, given in conjunction with rabies immune globulin, was supported and recommended by the United States Advisory Committee on Immunization Practices.

Full Text

Duke Authors

Cited Authors

  • Rupprecht, CE; Briggs, D; Brown, CM; Franka, R; Katz, SL; Kerr, HD; Lett, S; Levis, R; Meltzer, MI; Schaffner, W; Cieslak, PR

Published Date

  • November 27, 2009

Published In

Volume / Issue

  • 27 / 51

Start / End Page

  • 7141 - 7148

PubMed ID

  • 19925944

Electronic International Standard Serial Number (EISSN)

  • 1873-2518

Digital Object Identifier (DOI)

  • 10.1016/j.vaccine.2009.09.029


  • eng

Conference Location

  • Netherlands