Absence of normal keratan sulfate in the blood of patients with macular corneal dystrophy.


Journal Article

We measured levels of sulfated keratan sulfate in serum using a monoclonal antibody in an enzyme-linked immunosorbent assay. Sulfated keratan sulfate was not detected in the serum of 16 patients with macular corneal dystrophy, but was present at normal levels in 66 patients with other corneal diseases. There were no differences with respect to age, sex, and other ocular findings. This monoclonal antibody recognizes a sulfated carbohydrate epitope present in both corneal and skeletal keratan sulfate. Since most serum keratan sulfate is derived from the cartilages, the defect in keratan sulfate synthesis in macular corneal dystrophy may not be restricted to corneal cells. This assay should prove useful in the diagnosis of macular corneal dystrophy, particularly in children at risk before the appearance of opacification.

Full Text

Cited Authors

  • Thonar, EJ; Meyer, RF; Dennis, RF; Lenz, ME; Maldonado, B; Hassell, JR; Hewitt, AT; Stark, WJ; Stock, EL; Kuettner, KE

Published Date

  • November 15, 1986

Published In

Volume / Issue

  • 102 / 5

Start / End Page

  • 561 - 569

PubMed ID

  • 2946233

Pubmed Central ID

  • 2946233

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/0002-9394(86)90525-8


  • eng

Conference Location

  • United States