Rational theophylline use in older asthmatics.

Journal Article (Journal Article)

In the sick adult, the variability of clearance from patient to patient may be greater than 50%. A given dose of theophylline that is predicted to result in a serum concentration of 15 micrograms/ml may result in an actual range of serum concentrations from 6.6 to 33 micrograms/ml. Respiratory infections, both acute and chronic, seem to have an adverse effect on theophylline clearance. Studies in adults with acute viral upper respiratory infections, pneumonia, and chronic obstructive pulmonary disease show a significant decrease in clearance.

Full Text

Duke Authors

Cited Authors

  • Koenig, HG; Blake, RL

Published Date

  • August 1, 1986

Published In

Volume / Issue

  • 41 / 8

Start / End Page

  • 49 - 55

PubMed ID

  • 3732808

International Standard Serial Number (ISSN)

  • 0016-867X


  • eng

Conference Location

  • United States