The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients.

Journal Article

The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69+/-5.63 years; mean Hamilton Rating Scale for Depression score: 21+/-2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.

Full Text

Duke Authors

Cited Authors

  • Salloway, S; Boyle, PA; Correia, S; Malloy, PF; Cahn-Weiner, DA; Schneider, L; Krishnan, KRR; Nakra, R

Published Date

  • January 2002

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 107 - 111

PubMed ID

  • 11790641

Pubmed Central ID

  • 11790641

International Standard Serial Number (ISSN)

  • 1064-7481


  • eng

Conference Location

  • England