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The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients.

Publication ,  Journal Article
Salloway, S; Boyle, PA; Correia, S; Malloy, PF; Cahn-Weiner, DA; Schneider, L; Krishnan, KRR; Nakra, R
Published in: Am J Geriatr Psychiatry
2002

The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69+/-5.63 years; mean Hamilton Rating Scale for Depression score: 21+/-2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.

Duke Scholars

Published In

Am J Geriatr Psychiatry

ISSN

1064-7481

Publication Date

2002

Volume

10

Issue

1

Start / End Page

107 / 111

Location

England

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Sertraline
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Female
  • Depressive Disorder, Major
 

Citation

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MLA
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Salloway, S., Boyle, P. A., Correia, S., Malloy, P. F., Cahn-Weiner, D. A., Schneider, L., … Nakra, R. (2002). The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. Am J Geriatr Psychiatry, 10(1), 107–111.
Salloway, Stephen, Patricia A. Boyle, Stephen Correia, Paul F. Malloy, Deborah A. Cahn-Weiner, Lon Schneider, K Ranga Rama Krishnan, and Raj Nakra. “The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients.Am J Geriatr Psychiatry 10, no. 1 (2002): 107–11.
Salloway S, Boyle PA, Correia S, Malloy PF, Cahn-Weiner DA, Schneider L, et al. The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. Am J Geriatr Psychiatry. 2002;10(1):107–11.
Salloway, Stephen, et al. “The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients.Am J Geriatr Psychiatry, vol. 10, no. 1, 2002, pp. 107–11.
Salloway S, Boyle PA, Correia S, Malloy PF, Cahn-Weiner DA, Schneider L, Krishnan KRR, Nakra R. The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. Am J Geriatr Psychiatry. 2002;10(1):107–111.
Journal cover image

Published In

Am J Geriatr Psychiatry

ISSN

1064-7481

Publication Date

2002

Volume

10

Issue

1

Start / End Page

107 / 111

Location

England

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Sertraline
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Female
  • Depressive Disorder, Major