The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients.
Journal Article
The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69+/-5.63 years; mean Hamilton Rating Scale for Depression score: 21+/-2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.
Full Text
Duke Authors
Cited Authors
- Salloway, S; Boyle, PA; Correia, S; Malloy, PF; Cahn-Weiner, DA; Schneider, L; Krishnan, KRR; Nakra, R
Published Date
- January 2002
Published In
Volume / Issue
- 10 / 1
Start / End Page
- 107 - 111
PubMed ID
- 11790641
Pubmed Central ID
- 11790641
International Standard Serial Number (ISSN)
- 1064-7481
Language
- eng
Conference Location
- England