Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression.


Journal Article

BACKGROUND AND PURPOSE: Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited. METHODS: T2-weighted MRI scans in elderly depressed patients (n = 35) and normal comparison subjects (n = 31) were assessed for signal hyperintensities in lateralized discrete brain regions. RESULTS: Logistic regression revealed that left frontal deep white matter (P<.005) and left putaminal (P<.04) hyperintensities significantly predicted depressive group assignment. CONCLUSIONS: Findings suggest that greater neuroanatomic localization of hyperintensities than heretofore appreciated may relate to late-life depression.

Full Text

Duke Authors

Cited Authors

  • Greenwald, BS; Kramer-Ginsberg, E; Krishnan, KR; Ashtari, M; Auerbach, C; Patel, M

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 29 / 3

Start / End Page

  • 613 - 617

PubMed ID

  • 9506601

Pubmed Central ID

  • 9506601

International Standard Serial Number (ISSN)

  • 0039-2499

Digital Object Identifier (DOI)

  • 10.1161/01.str.29.3.613


  • eng

Conference Location

  • United States