Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression.
Published
Journal Article
BACKGROUND AND PURPOSE: Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited. METHODS: T2-weighted MRI scans in elderly depressed patients (n = 35) and normal comparison subjects (n = 31) were assessed for signal hyperintensities in lateralized discrete brain regions. RESULTS: Logistic regression revealed that left frontal deep white matter (P<.005) and left putaminal (P<.04) hyperintensities significantly predicted depressive group assignment. CONCLUSIONS: Findings suggest that greater neuroanatomic localization of hyperintensities than heretofore appreciated may relate to late-life depression.
Full Text
Duke Authors
Cited Authors
- Greenwald, BS; Kramer-Ginsberg, E; Krishnan, KR; Ashtari, M; Auerbach, C; Patel, M
Published Date
- March 1, 1998
Published In
Volume / Issue
- 29 / 3
Start / End Page
- 613 - 617
PubMed ID
- 9506601
Pubmed Central ID
- 9506601
International Standard Serial Number (ISSN)
- 0039-2499
Digital Object Identifier (DOI)
- 10.1161/01.str.29.3.613
Language
- eng
Conference Location
- United States