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A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease.

Publication ,  Journal Article
Parsey, RV; Krishnan, KR
Published in: Prog Neuropsychopharmacol Biol Psychiatry
November 1997

1. Alzheimer's Disease (AD) is accompanied by a disruption in iron metabolism. There is no universally accepted method for detecting brain iron. 2. The authors have developed a novel "ratio" method which uses the red nucleus as an internal reference. We postulated that this method would improve our sensitivity in detecting differences in MRI signal intensities and that it would allow us to measure brain iron deposition. 3. The ratio method reasonably reproduced previous reports of the normal deposition of iron in brain that occurs with aging. It failed to distinguish any differences in three brain areas: putamen, left frontal lobe and whole slice in AD patients versus age and sex matched controls. 4. It also failed to detect differences with AD progression or severity. 5. The ratio method itself warrants further investigation.

Duke Scholars

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

November 1997

Volume

21

Issue

8

Start / End Page

1257 / 1267

Location

England

Related Subject Headings

  • Putamen
  • Psychiatry
  • Middle Aged
  • Magnetic Resonance Imaging
  • Iron
  • Image Processing, Computer-Assisted
  • Humans
  • Brain Chemistry
  • Alzheimer Disease
  • Aging
 

Citation

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ICMJE
MLA
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Parsey, R. V., & Krishnan, K. R. (1997). A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry, 21(8), 1257–1267. https://doi.org/10.1016/s0278-5846(97)00162-0
Parsey, R. V., and K. R. Krishnan. “A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease.Prog Neuropsychopharmacol Biol Psychiatry 21, no. 8 (November 1997): 1257–67. https://doi.org/10.1016/s0278-5846(97)00162-0.
Parsey RV, Krishnan KR. A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 1997 Nov;21(8):1257–67.
Parsey, R. V., and K. R. Krishnan. “A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease.Prog Neuropsychopharmacol Biol Psychiatry, vol. 21, no. 8, Nov. 1997, pp. 1257–67. Pubmed, doi:10.1016/s0278-5846(97)00162-0.
Parsey RV, Krishnan KR. A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 1997 Nov;21(8):1257–1267.
Journal cover image

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

November 1997

Volume

21

Issue

8

Start / End Page

1257 / 1267

Location

England

Related Subject Headings

  • Putamen
  • Psychiatry
  • Middle Aged
  • Magnetic Resonance Imaging
  • Iron
  • Image Processing, Computer-Assisted
  • Humans
  • Brain Chemistry
  • Alzheimer Disease
  • Aging