Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.
Journal Article (Journal Article)
The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.
Full Text
Duke Authors
Cited Authors
- Stanley, M; Rotrosen, J; Sculerati, N; Gershon, S; Kuhn, C; Cohen, BM
Published Date
- 1979
Published In
Volume / Issue
- 66 / 1
Start / End Page
- 23 - 27
PubMed ID
- 44373
International Standard Serial Number (ISSN)
- 0033-3158
Digital Object Identifier (DOI)
- 10.1007/BF00431984
Language
- eng
Conference Location
- Germany