Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.

Journal Article (Journal Article)

The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

Full Text

Duke Authors

Cited Authors

  • Stanley, M; Rotrosen, J; Sculerati, N; Gershon, S; Kuhn, C; Cohen, BM

Published Date

  • 1979

Published In

Volume / Issue

  • 66 / 1

Start / End Page

  • 23 - 27

PubMed ID

  • 44373

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/BF00431984


  • eng

Conference Location

  • Germany