Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.
The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.
Stanley, M; Rotrosen, J; Sculerati, N; Gershon, S; Kuhn, C; Cohen, BM
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