Experimental dystonia induced by quaternary-chlorpromazine.

Published

Journal Article

When quaternary-chlorpromazine (Q-CPZ) was administered intraventricularly (ICV) to rats, it induced a lateralized dystonic reaction, which progressed to head-to-tail barrel rolling. The syndrome persisted for approximately 10 minutes, was not antagonized by pretreatment with drugs used to treat extrapyramidal movement disorders, and could not be mimicked by ICV administration of dopamine antagonists. Unlike known dopamine antagonists, Q-CPZ does not alter dopamine turnover, cause prolactin release in vivo, or bind to dopamine/neuroleptic receptors in vitro. These data suggest that Q-CPZ differs substantially from CPZ in pharmacologic action, and that it elicits a behavioral syndrome of potential use for studying dystonias.

Full Text

Duke Authors

Cited Authors

  • Rotrosen, J; Stanley, M; Kuhn, C; Wazer, D; Gershon, S

Published Date

  • August 1, 1980

Published In

Volume / Issue

  • 30 / 8

Start / End Page

  • 878 - 881

PubMed ID

  • 7191072

Pubmed Central ID

  • 7191072

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.30.8.878

Language

  • eng

Conference Location

  • United States