Lack of potency of metoclopramide's metabolites in various dopaminergic models.

Published

Journal Article

The dopaminergic properties of metoclopramide and four of its metabolites were determined in a series of in vivo and in vitro tests. In vivo measures included changes in dopamine turnover, serum prolactin levels and antagonism of apomorphine-induced stereotyped behavior. In each of these tests the four metabolites were either completely inactive or significantly less potent than the parent compound. The potency of metoclopramide and its metabolites in in vitro dopamine/neuroleptic receptor models was compared to the potency of standard reference compounds. In vitro results indicate that none of the four metabolites tested had antagonist activity in any of the receptor models in which they were evaluated. These findings will be discussed in light of the current understanding of receptor models as they relate to antipsychotic efficacy.

Full Text

Duke Authors

Cited Authors

  • Stanley, M; Wazer, D; Virgilio, J; Kuhn, CM; Benson, DI; Meyerson, LR

Published Date

  • February 1, 1983

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 263 - 266

PubMed ID

  • 6682229

Pubmed Central ID

  • 6682229

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(83)90372-6

Language

  • eng

Conference Location

  • United States