An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.

Published

Journal Article

Locomotor activity induced by d-amphetamine was found to be potentiated by food deprivation, a tryptophan-free diet, p-chlorophenylalanine and drugs proposed to antagonize serotonin receptors in brain. Administration of L-tryptophan 1 hour prior to d-amphetamine injection was found to antagonize the enhanced response to d-amphetamine in starved rats and in rats which had tryptophan removed from their diet. However, tryptophan did not block the potentiated response to d-amphetamine in animals pretreated with p-chlorophenylalanine. These findings suggested that the antagonism of d-amphetamine-induced activity by tryptophan in starved rats and rats fed a tryptophan-free diet was not due to a nonspecific depressant effect of the amino acid. Since accumulation of d-amphetamine and its metabolites was not affected by any of the treatments which enhanced its activity, it seems unlikely that an alteration in the metabolism of d-amphetamine can explain these findings. The present work provides additional support for the view that serotonergic fibers play an important role in the actions of d-amphetamine.

Full Text

Duke Authors

Cited Authors

  • Hollister, AS; Breese, GR; Kuhn, CM; Cooper, BR; Schanberg, SM

Published Date

  • July 1, 1976

Published In

Volume / Issue

  • 198 / 1

Start / End Page

  • 12 - 22

PubMed ID

  • 132524

Pubmed Central ID

  • 132524

International Standard Serial Number (ISSN)

  • 0022-3565

Language

  • eng

Conference Location

  • United States