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An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.

Publication ,  Journal Article
Hollister, AS; Breese, GR; Kuhn, CM; Cooper, BR; Schanberg, SM
Published in: J Pharmacol Exp Ther
July 1976

Locomotor activity induced by d-amphetamine was found to be potentiated by food deprivation, a tryptophan-free diet, p-chlorophenylalanine and drugs proposed to antagonize serotonin receptors in brain. Administration of L-tryptophan 1 hour prior to d-amphetamine injection was found to antagonize the enhanced response to d-amphetamine in starved rats and in rats which had tryptophan removed from their diet. However, tryptophan did not block the potentiated response to d-amphetamine in animals pretreated with p-chlorophenylalanine. These findings suggested that the antagonism of d-amphetamine-induced activity by tryptophan in starved rats and rats fed a tryptophan-free diet was not due to a nonspecific depressant effect of the amino acid. Since accumulation of d-amphetamine and its metabolites was not affected by any of the treatments which enhanced its activity, it seems unlikely that an alteration in the metabolism of d-amphetamine can explain these findings. The present work provides additional support for the view that serotonergic fibers play an important role in the actions of d-amphetamine.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

July 1976

Volume

198

Issue

1

Start / End Page

12 / 22

Location

United States

Related Subject Headings

  • Tryptophan
  • Stimulation, Chemical
  • Serotonin
  • Rats
  • Probenecid
  • Pharmacology & Pharmacy
  • Pargyline
  • Motor Activity
  • Male
  • Hydroxyindoleacetic Acid
 

Citation

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Hollister, A. S., Breese, G. R., Kuhn, C. M., Cooper, B. R., & Schanberg, S. M. (1976). An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine. J Pharmacol Exp Ther, 198(1), 12–22.
Hollister, A. S., G. R. Breese, C. M. Kuhn, B. R. Cooper, and S. M. Schanberg. “An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.J Pharmacol Exp Ther 198, no. 1 (July 1976): 12–22.
Hollister AS, Breese GR, Kuhn CM, Cooper BR, Schanberg SM. An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine. J Pharmacol Exp Ther. 1976 Jul;198(1):12–22.
Hollister, A. S., et al. “An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.J Pharmacol Exp Ther, vol. 198, no. 1, July 1976, pp. 12–22.
Hollister AS, Breese GR, Kuhn CM, Cooper BR, Schanberg SM. An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine. J Pharmacol Exp Ther. 1976 Jul;198(1):12–22.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

July 1976

Volume

198

Issue

1

Start / End Page

12 / 22

Location

United States

Related Subject Headings

  • Tryptophan
  • Stimulation, Chemical
  • Serotonin
  • Rats
  • Probenecid
  • Pharmacology & Pharmacy
  • Pargyline
  • Motor Activity
  • Male
  • Hydroxyindoleacetic Acid