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The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer.

Publication ,  Journal Article
Takami, Y; Higashi, M; Kumagai, S; Kuo, PC; Kawana, H; Koda, K; Miyazaki, M; Harigaya, K
Published in: Dig Dis Sci
February 2008

Rho family GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. To evaluate the role of these GTPases in colorectal cancer, the protein expression levels and activities of these proteins in matched sets of tumor and non-tumor tissues of surgical specimens were analyzed. The relationship between the protein levels and activities in tumor tissues to the clinicopathological features was also assessed. The expression levels of RhoA, active RhoA, Rac1, and active Rac1 in tumor tissues were higher than in normal tissues. The amounts of active RhoA protein in primary tumors correlated with lymph nodes metastasis. No relationship was noted between the protein expression levels and other clinicopathological findings. These findings suggest that the Rho family small GTPases are related to malignant transformation and progression of colorectal cancer and the activation of RhoA is associated with the lymph node metastasis.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

February 2008

Volume

53

Issue

2

Start / End Page

467 / 473

Location

United States

Related Subject Headings

  • rhoA GTP-Binding Protein
  • rac1 GTP-Binding Protein
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Enzyme Activation
  • Disease Progression
 

Citation

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Takami, Y., Higashi, M., Kumagai, S., Kuo, P. C., Kawana, H., Koda, K., … Harigaya, K. (2008). The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Dig Dis Sci, 53(2), 467–473. https://doi.org/10.1007/s10620-007-9887-0
Takami, Yoji, Morihiro Higashi, Shinpei Kumagai, Paul C. Kuo, Hidetada Kawana, Keiji Koda, Masaru Miyazaki, and Kenichi Harigaya. “The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer.Dig Dis Sci 53, no. 2 (February 2008): 467–73. https://doi.org/10.1007/s10620-007-9887-0.
Takami Y, Higashi M, Kumagai S, Kuo PC, Kawana H, Koda K, et al. The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Dig Dis Sci. 2008 Feb;53(2):467–73.
Takami, Yoji, et al. “The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer.Dig Dis Sci, vol. 53, no. 2, Feb. 2008, pp. 467–73. Pubmed, doi:10.1007/s10620-007-9887-0.
Takami Y, Higashi M, Kumagai S, Kuo PC, Kawana H, Koda K, Miyazaki M, Harigaya K. The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Dig Dis Sci. 2008 Feb;53(2):467–473.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

February 2008

Volume

53

Issue

2

Start / End Page

467 / 473

Location

United States

Related Subject Headings

  • rhoA GTP-Binding Protein
  • rac1 GTP-Binding Protein
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Enzyme Activation
  • Disease Progression