Comparing the effects of antidepressants: consensus guidelines for evaluating quantitative reviews of antidepressant efficacy.

Journal Article (Journal Article;Review)

With increasing numbers of treatment options available for patients with major depression over the last decade and the growing body of evidence describing their efficacy and safety, clinicians often find it difficult to determine the best and most appropriate evidence-based treatment for each patient. Systematic reviews utilizing statistical methods that synthesize and evaluate data from a number of studies have become increasingly more available over the past decade. We review major findings and lessons learned from salient examples of quantitative analyses of antidepressant research and provide recommendations for meta-analysts, journal and grant reviewers, and research 'consumers' (ie, clinicians) for conducting, reporting, and evaluating such analyses.

Full Text

Duke Authors

Cited Authors

  • Lieberman, JA; Greenhouse, J; Hamer, RM; Krishnan, KR; Nemeroff, CB; Sheehan, DV; Thase, ME; Keller, MB

Published Date

  • March 2005

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 445 - 460

PubMed ID

  • 15647752

International Standard Serial Number (ISSN)

  • 0893-133X

Digital Object Identifier (DOI)

  • 10.1038/sj.npp.1300571


  • eng

Conference Location

  • England