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A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.

Publication ,  Journal Article
Mattson, RH; Cramer, JA; Delgado Escueta, AV; Smith, DB; Collins, JF
Published in: Neurology
March 1983

The design for the comparative evaluation of the efficacy and toxicity of phenobarbital, phenytoin, primidone, and carbamazepine is outlined. A double-blind prospective study of a sufficient number of patients can determine the optimum drug to use initially for partial and generalized tonic-clonic seizures in adults. The rationale for methods defines the major parameters that should be addressed in order to determine optimum drug for longterm seizure therapy. Major problems in the function of such a project include aspects of sample size attainment, screening/recruitment, non-drug-related losses, and adjustments to the ongoing protocol. The design, with modifications, can be used to study other antiepileptic drugs and other types of seizures.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

March 1983

Volume

33

Issue

3 Suppl 1

Start / End Page

14 / 25

Location

United States

Related Subject Headings

  • Seizures
  • Random Allocation
  • Primidone
  • Phenytoin
  • Phenobarbital
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Epilepsy
  • Electroencephalography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mattson, R. H., Cramer, J. A., Delgado Escueta, A. V., Smith, D. B., & Collins, J. F. (1983). A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults. Neurology, 33(3 Suppl 1), 14–25. https://doi.org/10.1212/wnl.33.3_suppl_1.14
Mattson, R. H., J. A. Cramer, A. V. Delgado Escueta, D. B. Smith, and J. F. Collins. “A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.Neurology 33, no. 3 Suppl 1 (March 1983): 14–25. https://doi.org/10.1212/wnl.33.3_suppl_1.14.
Mattson RH, Cramer JA, Delgado Escueta AV, Smith DB, Collins JF. A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults. Neurology. 1983 Mar;33(3 Suppl 1):14–25.
Mattson, R. H., et al. “A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.Neurology, vol. 33, no. 3 Suppl 1, Mar. 1983, pp. 14–25. Pubmed, doi:10.1212/wnl.33.3_suppl_1.14.
Mattson RH, Cramer JA, Delgado Escueta AV, Smith DB, Collins JF. A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults. Neurology. 1983 Mar;33(3 Suppl 1):14–25.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

March 1983

Volume

33

Issue

3 Suppl 1

Start / End Page

14 / 25

Location

United States

Related Subject Headings

  • Seizures
  • Random Allocation
  • Primidone
  • Phenytoin
  • Phenobarbital
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Epilepsy
  • Electroencephalography