Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.

Journal Article (Journal Article)

Repeated seizures, whether induced by kindling or electroshock, caused a long-lasting (at least 24 hr) increase of [3H]diazepam binding in hippocampal membranes of Sprague-Dawley rats. Scatchard analyses demonstrated that increased numbers of binding sites accounted for the increase. Neither repeated hypoxia nor repeated administration of electrical current without inducing seizures caused an increase of [3H]diazepam binding. Regardless of the method used for seizure induction, the response was graded in that large numbers of seizures were required to induce significant increases, whereas fewer seizures induced only slight increases. We suggest that the receptor increases imply a heightened response to benzodiazepines and more powerful hippocampal recurrent inhibition.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO; Peper, AM; Patrone, V

Published Date

  • May 1980

Published In

Volume / Issue

  • 77 / 5

Start / End Page

  • 3029 - 3032

PubMed ID

  • 6930682

Pubmed Central ID

  • PMC349540

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.77.5.3029


  • eng

Conference Location

  • United States