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Selective biliary secretion of basal and glucagon-inhibited neutral sterol after triparanol administration.

Publication ,  Journal Article
Meyers, WC; Hanks, JB; Jakoi, L; Quarfordt, S; Jones, RS
Published in: Surgery
July 1980

Biliary cholesterol secretion was studied in dogs with chronic bile fistulas, using glucagon, an inhibitor of biliary cholesterol secretion, and triparanol, an inhibitor of cholesterol synthesis. Glucagon inhibited neutral sterol secretion before and after triparanol administration. Triparanol caused a significant accumulation in bile of the cholesterol precursor desmosterol which comprised a significant portion of the neutral sterol in bile but not in blood. Glucagon inhibited both biliary desmosterol and cholesterol secretions to a similar degree. These findings suggest that biliary cholesterol is derived from newly synthesized hepatic sterol as well as from equilibrated sources. Furthermore, glucagon suppressed biliary secretion of both equilibrated as well as newly synthesized neutral sterol, suggesting that glucagon inhibits the movement of neutral sterol to or through the canalicular membrane.

Duke Scholars

Published In

Surgery

ISSN

0039-6060

Publication Date

July 1980

Volume

88

Issue

1

Start / End Page

156 / 161

Location

United States

Related Subject Headings

  • Triparanol
  • Surgery
  • Secretory Rate
  • Glucagon
  • Female
  • Dogs
  • Desmosterol
  • Cholesterol
  • Bile Ducts
  • Bile Acids and Salts
 

Citation

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Meyers, W. C., Hanks, J. B., Jakoi, L., Quarfordt, S., & Jones, R. S. (1980). Selective biliary secretion of basal and glucagon-inhibited neutral sterol after triparanol administration. Surgery, 88(1), 156–161.
Meyers, W. C., J. B. Hanks, L. Jakoi, S. Quarfordt, and R. S. Jones. “Selective biliary secretion of basal and glucagon-inhibited neutral sterol after triparanol administration.Surgery 88, no. 1 (July 1980): 156–61.
Meyers WC, Hanks JB, Jakoi L, Quarfordt S, Jones RS. Selective biliary secretion of basal and glucagon-inhibited neutral sterol after triparanol administration. Surgery. 1980 Jul;88(1):156–61.
Meyers, W. C., et al. “Selective biliary secretion of basal and glucagon-inhibited neutral sterol after triparanol administration.Surgery, vol. 88, no. 1, July 1980, pp. 156–61.
Meyers WC, Hanks JB, Jakoi L, Quarfordt S, Jones RS. Selective biliary secretion of basal and glucagon-inhibited neutral sterol after triparanol administration. Surgery. 1980 Jul;88(1):156–161.
Journal cover image

Published In

Surgery

ISSN

0039-6060

Publication Date

July 1980

Volume

88

Issue

1

Start / End Page

156 / 161

Location

United States

Related Subject Headings

  • Triparanol
  • Surgery
  • Secretory Rate
  • Glucagon
  • Female
  • Dogs
  • Desmosterol
  • Cholesterol
  • Bile Ducts
  • Bile Acids and Salts