Bile flow--an index of ischemic injury.

Published

Journal Article

Bile formation is an active secretory process involving bile salt-dependent and -"independent" mechanisms. This study was performed to determine the effect of selected periods of warm ischemia on biliary secretion. Rats were studied using an in situ liver perfusion system after stabilization of bile flow with intravenous sodium taurocholate. Bile flow remained stable in control livers and ceased during ischemic periods of 15 or 25 min. After reperfusion of 15-min ischemic livers, bile flow was depressed but returned to normal by 45 min of reperfusion. After 25 min of ischemia, bile flow remained depressed. A similar depression in bile salt secretion was observed. These studies indicate that both bile flow and bile salt secretion reflect the degree of ischemia in this isolated perfused system, and further use of this model for the investigation of biliary flow as an index of ischemic injury is warranted.

Full Text

Duke Authors

Cited Authors

  • Bowers, BA; Branum, GD; Rotolo, FS; Watters, CR; Meyers, WC

Published Date

  • May 1987

Published In

Volume / Issue

  • 42 / 5

Start / End Page

  • 565 - 569

PubMed ID

  • 3586626

Pubmed Central ID

  • 3586626

Electronic International Standard Serial Number (EISSN)

  • 1095-8673

International Standard Serial Number (ISSN)

  • 0022-4804

Digital Object Identifier (DOI)

  • 10.1016/0022-4804(87)90033-3

Language

  • eng