Abnormal development of blood pressure and growth in rats exposed to perinatal injection stress.


Journal Article

Subcutaneous injections of alkaline saline were made perinatally in Sprague-Dawley rats according to two schedules. In a pre-/postnatal group, dams were treated from 19th gestational day to 9th day postpartum and pups from day 0-9. In a postnatal group, pups alone were injected from day 0-6. At 19-23, 50-56 and 82-86 days of age, injected rats and uninjected controls were anesthetized and arterial blood pressure measured. Rats from the pre-/postnatal group had higher blood pressures (58%) and body weights at 19-23 days and lower blood pressure (35%) and body weight at 82-86 days of age. Blood pressure and body weight were comparable to control at all ages in the postnatal injection group. It is concluded that as a result of the maternal stress produced by the injections there was a generalized disturbance of growth processes resulting in hypotension and decreased body weight in adulthood.

Full Text

Duke Authors

Cited Authors

  • Smith, PG; Mills, E

Published Date

  • May 23, 1983

Published In

Volume / Issue

  • 32 / 21

Start / End Page

  • 2497 - 2501

PubMed ID

  • 6855452

Pubmed Central ID

  • 6855452

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(83)90376-4


  • eng

Conference Location

  • Netherlands