Abnormal development of blood pressure and growth in rats exposed to perinatal injection stress.
Published
Journal Article
Subcutaneous injections of alkaline saline were made perinatally in Sprague-Dawley rats according to two schedules. In a pre-/postnatal group, dams were treated from 19th gestational day to 9th day postpartum and pups from day 0-9. In a postnatal group, pups alone were injected from day 0-6. At 19-23, 50-56 and 82-86 days of age, injected rats and uninjected controls were anesthetized and arterial blood pressure measured. Rats from the pre-/postnatal group had higher blood pressures (58%) and body weights at 19-23 days and lower blood pressure (35%) and body weight at 82-86 days of age. Blood pressure and body weight were comparable to control at all ages in the postnatal injection group. It is concluded that as a result of the maternal stress produced by the injections there was a generalized disturbance of growth processes resulting in hypotension and decreased body weight in adulthood.
Full Text
Duke Authors
Cited Authors
- Smith, PG; Mills, E
Published Date
- May 23, 1983
Published In
Volume / Issue
- 32 / 21
Start / End Page
- 2497 - 2501
PubMed ID
- 6855452
Pubmed Central ID
- 6855452
International Standard Serial Number (ISSN)
- 0024-3205
Digital Object Identifier (DOI)
- 10.1016/0024-3205(83)90376-4
Language
- eng
Conference Location
- Netherlands