Abnormal functional development of sympathetic nerve terminal-smooth muscle complex in neonatal spontaneously hypertensive rats.


Journal Article

In neonatal and young adult SH and WK rats, maturation of a functional unit consisting of sympathetic nerve terminals and smooth muscle (levator palpebrae) was assessed in vivo by measuring the contractile response to tyramine, an agent which releases endogenous norepinephrine from sympathetic nerve terminals. Responses in SH are comparable to WK at 5-6 days postnatally, smaller from the 8th through 19th day and larger in young adults (41-46 days old). Results indicate that functional maturation of the nerve terminal-smooth muscle complex is retarded in SH relative to WK during the 2nd and 3rd postnatal weeks. It is suggested that retardation in the neonatal SH rat is an expression of a genetic defect in the growth of the complex and that the enhanced response in young adult SH is a consequence of the neonatal abnormality.

Full Text

Duke Authors

Cited Authors

  • Smith, PG; Poston, CW; Mills, E

Published Date

  • August 30, 1982

Published In

Volume / Issue

  • 31 / 9

Start / End Page

  • 889 - 892

PubMed ID

  • 7176818

Pubmed Central ID

  • 7176818

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(82)90545-8


  • eng

Conference Location

  • Netherlands