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Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.

Publication ,  Journal Article
Hartz, SM; Short, SE; Saccone, NL; Culverhouse, R; Chen, L; Schwantes-An, T-H; Coon, H; Han, Y; Stephens, SH; Sun, J; Chen, X; Ducci, F ...
Published in: Arch Gen Psychiatry
August 2012
Published version (DOI) Link to item

CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers.

Duke Scholars

Qingyi Wei
Author Qingyi Wei Population Health Sciences
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Published In

Arch Gen Psychiatry

DOI

10.1001/archgenpsychiatry.2012.124

EISSN

1538-3636

Publication Date

August 2012

Volume

69

Issue

8

Start / End Page

854 / 860

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Smoking
  • Severity of Illness Index
  • Receptors, Nicotinic
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Nicotine
  • Nerve Tissue Proteins
  • Male
  • Humans
 

Citation

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Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L., Schwantes-An, T.-H., … Bierut, L. J. (2012). Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry, 69(8), 854–860. https://doi.org/10.1001/archgenpsychiatry.2012.124
Hartz, Sarah M., Susan E. Short, Nancy L. Saccone, Robert Culverhouse, LiShiun Chen, Tae-Hwi Schwantes-An, Hilary Coon, et al. “Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.” Arch Gen Psychiatry 69, no. 8 (August 2012): 854–60. https://doi.org/10.1001/archgenpsychiatry.2012.124.
Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An T-H, et al. Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry. 2012 Aug;69(8):854–60.
Hartz, Sarah M., et al. “Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.” Arch Gen Psychiatry, vol. 69, no. 8, Aug. 2012, pp. 854–60. Pubmed, doi:10.1001/archgenpsychiatry.2012.124.
Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An T-H, Coon H, Han Y, Stephens SH, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel NN, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen L-P, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao X, Yang B-Z, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen J, Cheng Y-C, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Hayward C, Heikkilä K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi M-T, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma DI, Caporaso N, Duan J, Edenberg HJ, Francks C, Gejman PV, Gelernter J, Grabe HJ, Hops H, Jarvelin M-R, Viikari J, Kähönen M, Kendler KS, Lehtimäki T, Levinson DF, Marazita ML, Marchini J, Melbye M, Mitchell BD, Murray JC, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Sanders AR, Schwartz AG, Shete S, Shi J, Spitz M, Stefansson K, Swan GE, Thorgeirsson T, Völzke H, Wei Q, Wichmann H-E, Amos CI, Breslau N, Cannon DS, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, Bierut LJ. Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry. 2012 Aug;69(8):854–860.

Published In

Arch Gen Psychiatry

DOI

10.1001/archgenpsychiatry.2012.124

EISSN

1538-3636

Publication Date

August 2012

Volume

69

Issue

8

Start / End Page

854 / 860

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Smoking
  • Severity of Illness Index
  • Receptors, Nicotinic
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Nicotine
  • Nerve Tissue Proteins
  • Male
  • Humans